The overall aim of this NEI Core Grant for Vision Research is to facilitate the application of important technologies in the analysis of the structure, function and disease mechanisms that affect the visual system. The long-term goal of the investigators served by this grant is to preventing blindness and restoring vision. To this end we will develop a series of core modules that will provide state-of-the-art instrumentation and technologies required for vision research. The three core modules are: (1) Ocular Imaging Module; (2) Functional Vision Module; and (3) Molecular Informatics Module. These modules contain equipment that will be maintained and operated by highly skilled technicians that are supervised by established R01 funded investigators. Consolidating these technologies into these modules allow us to bring these techniques and skills to all potential users in our program, which we anticipate will increase productivity in the user laboratories and avoid duplication of equipment and effort. Successful operation of these three modules will bring the best of these technologies to each of the NEI RO1 supported laboratories in this institution. We also envision that these core modules will enhance and sustain the collaborative scientific environment that is a strong feature of the research group supported by these modules. The modules will also enhance productivity and increase collaboration among the participating investigators. These modules will also allow junior investigators to have access to services and research strategies that will help generate preliminary data to support new RO1 application.

Public Health Relevance

The overall aim of this NEI Core Grant for Vision Research is to facilitate the application of important technologies in the analysis of the structure, function and disease mechanisms that affect the visual system. The long-term goal of the investigators served by this grant is to prevent blindness and restore vision. To this end we will develop a series of core modules that will provide state-of-the-art instrumentation and technologies required for vision research

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
1P30EY025585-01A1
Application #
9153314
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Liberman, Ellen S
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
1
Fiscal Year
2016
Total Cost
$618,205
Indirect Cost
$218,205
Name
Cleveland Clinic Lerner
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Choi, Elliot H; Suh, Susie; Sander, Christopher L et al. (2018) Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet 27:2225-2243
Zhang, Lingjun; Li, Yan; Qiu, Wen et al. (2018) Targeting CD6 for the treatment of experimental autoimmune uveitis. J Autoimmun 90:84-93
Orban, Tivadar; Leinonen, Henri; Getter, Tamar et al. (2018) A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther 364:207-220
Zhao, Yue; Chundury, Rao V; Blandford, Alexander D et al. (2018) Anatomical Description of Zygomatic Foramina in African American Skulls. Ophthalmic Plast Reconstr Surg 34:168-171
Tarchick, Matthew J; Cutler, Alecia H; Trobenter, Timothy D et al. (2018) Endogenous insulin signaling in the RPE contributes to the maintenance of rod photoreceptor function in diabetes. Exp Eye Res 180:63-74
Kiser, Philip D; Zhang, Jianye; Sharma, Aditya et al. (2018) Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol 150:571-590
Blandford, Alexander D; Cherfan, Daniel G; Drake, Richard L et al. (2018) Continuous Positive Airway Pressure Thresholds for Nasolacrimal Air Regurgitation in a Cadaveric Model. Ophthalmic Plast Reconstr Surg 34:440-442
Medeiros, Carla S; Lassance, Luciana; Saikia, Paramananda et al. (2018) Posterior stromal cell apoptosis triggered by mechanical endothelial injury and basement membrane component nidogen-1 production in the cornea. Exp Eye Res 172:30-35
Kinoshita, Junzo; Peachey, Neal S (2018) Noninvasive Electroretinographic Procedures for the Study of the Mouse Retina. Curr Protoc Mouse Biol 8:1-16
Pollock, Lana M; Xie, Jing; Bell, Brent A et al. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB J 32:5674-5684

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