Abstract

Ocular Imaging Module The Ocular Imaging Module will provide a variety of imaging modalities to the investigators involved in this P30 Core Grant for Vision Research. The module includes live animal (in vivo) imaging with slit lamp and fundus photography, scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT). It also supports tissue and cellular imaging (ex vivo) support, providing routine and specialized tissue fixation techniques, paraffin and plastic tissue embedding, sectioning (paraffin and Cryo) and staining for immunohistochemistry. Microscope imaging techniques include bright field, dark field, differential interference contrast (DIC), fluorescence, and transmission electron microscopy (TEM). It also provides help and advice with the morphometric analysis of generated images. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025585-02
Application #
9336309
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Medeiros, Carla S; Marino, Gustavo K; Lassance, Luciana et al. (2018) The Impact of Photorefractive Keratectomy and Mitomycin C on Corneal Nerves and Their Regeneration. J Refract Surg 34:790-798
Senanayake, Preenie deS; Bonilha, Vera L; W Peterson, John et al. (2018) Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril. J Renin Angiotensin Aldosterone Syst 19:1470320318789323
Lassance, Luciana; Marino, Gustavo K; Medeiros, Carla S et al. (2018) Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury. Exp Eye Res 170:177-187
Wilson, Steven E; Medeiros, Carla S; Santhiago, Marcony R (2018) Pathophysiology of Corneal Scarring in Persistent Epithelial Defects After PRK and Other Corneal Injuries. J Refract Surg 34:59-64
Blandford, Alexander D; Hwang, Catherine J; Young, Jason et al. (2018) Microanatomical Location of Hyaluronic Acid Gel Following Injection of the Upper Lip Vermillion Border: Comparison of Needle and Microcannula Injection Technique. Ophthalmic Plast Reconstr Surg 34:296-299
Song, Ping; Perkins, Brian D (2018) Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b. Gene Expr Patterns 29:82-87
Gulati, Sahil; Jin, Hui; Masuho, Ikuo et al. (2018) Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun 9:1996
Chan, Jonathan K L; Yuen, Don; Too, Priscilla Hiu-Mei et al. (2018) Keratin 6a reorganization for ubiquitin-proteasomal processing is a direct antimicrobial response. J Cell Biol 217:731-744
Dhingra, Anuradha; Bell, Brent A; Peachey, Neal S et al. (2018) Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium. Front Cell Neurosci 12:351
Swarup, Aditi; Bell, Brent A; Du, Jianhai et al. (2018) Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res 172:45-53

Showing the most recent 10 out of 40 publications