Functional Vision Module The Functional Vision Module will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Core Grant for Vision Research. This module will provide state of the art assessment of visual function in mice and zebrafish. Included are visual electrophysiological assays such as the electroretinogram (ERG) and the visual evoked potential (VEP); and visual behavior assays such as the pupillary light reflex (PLR), the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025585-02
Application #
9336310
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
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Santhanam, Abirami; Marino, Gustavo K; Torricelli, Andre A M et al. (2017) EBM regeneration and changes in EBM component mRNA expression in stromal cells after corneal injury. Mol Vis 23:39-51
Kiser, Philip D; Zhang, Jianye; Badiee, Mohsen et al. (2017) Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther 362:131-145
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Marino, Gustavo K; Santhiago, Marcony R; Santhanam, Abirami et al. (2017) Epithelial basement membrane injury and regeneration modulates corneal fibrosis after pseudomonas corneal ulcers in rabbits. Exp Eye Res 161:101-105
Bonilha, Vera L; Bell, Brent A; Rayborn, Mary E et al. (2017) Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress. Free Radic Biol Med 104:226-237
Blandford, Alexander D; Hwang, Catherine J; Young, Jason et al. (2017) Microanatomical Location of Hyaluronic Acid Gel Following Injection of the Upper Lip Vermillion Border: Comparison of Needle and Microcannula Injection Technique. Ophthal Plast Reconstr Surg :

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