Abstract

Functional Vision Module The Functional Vision Module will provide the technologies required to interrogate visual function in experimental animals to the investigators involved in this P30 Core Grant for Vision Research. This module will provide state of the art assessment of visual function in mice and zebrafish. Included are visual electrophysiological assays such as the electroretinogram (ERG) and the visual evoked potential (VEP); and visual behavior assays such as the pupillary light reflex (PLR), the optokinetic reflex (OKR), optomotor reflex (OMR) and threshold measurement. Collectively, these assays interrogate visual function from light detection in the photoreceptors to signal integration and interpretation within the brain. Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY025585-02
Application #
9336310
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Blandford, Alexander D; Cherfan, Daniel G; Drake, Richard L et al. (2018) Continuous Positive Airway Pressure Thresholds for Nasolacrimal Air Regurgitation in a Cadaveric Model. Ophthalmic Plast Reconstr Surg 34:440-442
Medeiros, Carla S; Lassance, Luciana; Saikia, Paramananda et al. (2018) Posterior stromal cell apoptosis triggered by mechanical endothelial injury and basement membrane component nidogen-1 production in the cornea. Exp Eye Res 172:30-35
Kinoshita, Junzo; Peachey, Neal S (2018) Noninvasive Electroretinographic Procedures for the Study of the Mouse Retina. Curr Protoc Mouse Biol 8:1-16
Pollock, Lana M; Xie, Jing; Bell, Brent A et al. (2018) Retinoic acid signaling is essential for maintenance of the blood-retinal barrier. FASEB J 32:5674-5684
Miller, Andrew H; Howe, Hollis B; Krause, Bryan M et al. (2018) Pregnancy-Associated Plasma Protein-aa Regulates Photoreceptor Synaptic Development to Mediate Visually Guided Behavior. J Neurosci 38:5220-5236
Saikia, Paramananda; Thangavadivel, Shanmugapriya; Medeiros, Carla S et al. (2018) IL-1 and TGF-? Modulation of Epithelial Basement Membrane Components Perlecan and Nidogen Production by Corneal Stromal Cells. Invest Ophthalmol Vis Sci 59:5589-5598
Saikia, Paramananda; Medeiros, Carla S; Thangavadivel, Shanmugapriya et al. (2018) Basement membranes in the cornea and other organs that commonly develop fibrosis. Cell Tissue Res 374:439-453
Medeiros, Carla S; Marino, Gustavo K; Lassance, Luciana et al. (2018) The Impact of Photorefractive Keratectomy and Mitomycin C on Corneal Nerves and Their Regeneration. J Refract Surg 34:790-798
Senanayake, Preenie deS; Bonilha, Vera L; W Peterson, John et al. (2018) Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril. J Renin Angiotensin Aldosterone Syst 19:1470320318789323
Lassance, Luciana; Marino, Gustavo K; Medeiros, Carla S et al. (2018) Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury. Exp Eye Res 170:177-187

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