The Center of Biomedical Research Excellence for Research on Processes in Evolution at the University of Idaho is organized under the auspices of the Institute for Bioinformatics and Evolutionary Studies (IBEST). For the past 10 years, COBRE funding enabled IBEST investigators to conduct leading-edge interdisciplinary research in computational and evolutionary biology and to mentor early faculty to develop nationally competitive, independently-funded research programs. Faculty who graduate to independent funding remain in the highly collaborative community of IBEST. The Computational Resources Core and Genomics Resources Core facilities established as part of this COBRE provide a diverse array of advanced instrumentation and computational resources, as well as technical support to investigators. These core facilities currently support 28 funded projects. Thus, COBRE funding has had the intended effect of strengthening the institution's biomedical research capabilities and cultivating the supportive research environment needed to be competitive for external funding. Many of these projects are interdisciplinary collaborations between biologists and mathematicians, statisticians or computer scientists, and require the resources of both core facilities. Phase III has three Specific Objectives: 1. To complete these two research cores and to transition them to sustainability in a way that will continue to support the research of IBEST. 2. To support a Research Pilot Project Program, Technology Access Grants, and Travel and Collaboration Grants. The first two programs will enable faculty to generate preliminary data that will make them more competitive for external funding, and the third will enable them to initiate and/or develop collaborations that support research. 3. Through a new Strategic Plan, identify scientific opportunities through frequent interactions within IBEST and extensive interactions with the external scientific community. This final phase of COBRE funding, along with institutional investments in IBEST as a strategic Institute, will ensure our self-sustainability and maintain the infrastructure, climate, funding an personnel needed for a vibrant biomedical research program focused on processes of evolution.
The pathogens and parasites evolved in real time, leading to drug resistance, vaccine failures, host switching, and emergent diseases. These human health problems arise through evolutionary processes, so treatment, and prevention require an understanding of how organisms respond to selective pressure and what factures influence extant diversity and drive the tempo and trajectory of evolutionary processes.
|Trumbo, Daryl R; Epstein, Brendan; Hohenlohe, Paul A et al. (2016) Mixed population genomics support for the central marginal hypothesis across the invasive range of the cane toad (Rhinella marina) in Australia. Mol Ecol 25:4161-76|
|Funk, W Chris; Lovich, Robert E; Hohenlohe, Paul A et al. (2016) Adaptive divergence despite strong genetic drift: genomic analysis of the evolutionary mechanisms causing genetic differentiation in the island fox (Urocyon littoralis). Mol Ecol 25:2176-94|
|Magalhaes, Isabel S; D'Agostino, Daniele; Hohenlohe, Paul A et al. (2016) The ecology of an adaptive radiation of three-spined stickleback from North Uist, Scotland. Mol Ecol 25:4319-36|
|Fernandes, K A; Bloomsburg, S J; Miller, C J et al. (2016) Novel axon projection after stress and degeneration in the Dscam mutant retina. Mol Cell Neurosci 71:1-12|
|Kim, M-S; Hohenlohe, P A; Kim, K-H et al. (2016) Genetic diversity and population structure of Raffaelea quercus-mongolicae, a fungus associated with oak mortality in South Korea. Forest pathology 46:164-167|
|Simmons, Aaron B; Bloomsburg, Samuel J; Billingslea, Samuel A et al. (2016) Pou4f2 knock-in Cre mouse: A multifaceted genetic tool for vision researchers. Mol Vis 22:705-17|
|Simmons, Aaron B; Merrill, Morgan M; Reed, Justin C et al. (2016) Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination. Invest Ophthalmol Vis Sci 57:1563-77|
|Shen, Jian; Song, Ning; Williams, Christopher J et al. (2016) Effects of low dose estrogen therapy on the vaginal microbiomes of women with atrophic vaginitis. Sci Rep 6:24380|
|Shi, Xun; Tarazona, Pablo; Brock, Trisha J et al. (2016) A Caenorhabditis elegans model for ether lipid biosynthesis and function. J Lipid Res 57:265-75|
|Epstein, Brendan; Jones, Menna; Hamede, Rodrigo et al. (2016) Rapid evolutionary response to a transmissible cancer in Tasmanian devils. Nat Commun 7:12684|
Showing the most recent 10 out of 39 publications