The Center of Biomedical Research Excellence for Research on Processes in Evolution at the University of Idaho is organized under the auspices of the Institute for Bioinformatics and Evolutionary Studies (IBEST). For the past 10 years, COBRE funding enabled IBEST investigators to conduct leading-edge interdisciplinary research in computational and evolutionary biology and to mentor early faculty to develop nationally competitive, independently-funded research programs. Faculty who graduate to independent funding remain in the highly collaborative community of IBEST. The Computational Resources Core and Genomics Resources Core facilities established as part of this COBRE provide a diverse array of advanced instrumentation and computational resources, as well as technical support to investigators. These core facilities currently support 28 funded projects. Thus, COBRE funding has had the intended effect of strengthening the institution's biomedical research capabilities and cultivating the supportive research environment needed to be competitive for external funding. Many of these projects are interdisciplinary collaborations between biologists and mathematicians, statisticians or computer scientists, and require the resources of both core facilities. Phase III has three Specific Objectives: 1. To complete these two research cores and to transition them to sustainability in a way that will continue to support the research of IBEST. 2. To support a Research Pilot Project Program, Technology Access Grants, and Travel and Collaboration Grants. The first two programs will enable faculty to generate preliminary data that will make them more competitive for external funding, and the third will enable them to initiate and/or develop collaborations that support research. 3. Through a new Strategic Plan, identify scientific opportunities through frequent interactions within IBEST and extensive interactions with the external scientific community. This final phase of COBRE funding, along with institutional investments in IBEST as a strategic Institute, will ensure our self-sustainability and maintain the infrastructure, climate, funding an personnel needed for a vibrant biomedical research program focused on processes of evolution.
The pathogens and parasites evolved in real time, leading to drug resistance, vaccine failures, host switching, and emergent diseases. These human health problems arise through evolutionary processes, so treatment, and prevention require an understanding of how organisms respond to selective pressure and what factures influence extant diversity and drive the tempo and trajectory of evolutionary processes.
|Damase, Tulsi Ram; Miura, Tanya A; Parent, Christine E et al. (2018) Application of the Open qPCR Instrument for the in Vitro Selection of DNA Aptamers against Epidermal Growth Factor Receptor and Drosophila C Virus. ACS Comb Sci 20:45-54|
|Sun, Chi; Mitchell, Diana M; Stenkamp, Deborah L (2018) Isolation of photoreceptors from mature, developing, and regenerated zebrafish retinas, and of microglia/macrophages from regenerating zebrafish retinas. Exp Eye Res 177:130-144|
|Miller, Craig R; Van Leuven, James T; Wichman, Holly A et al. (2018) Selecting among three basic fitness landscape models: Additive, multiplicative and stickbreaking. Theor Popul Biol 122:97-109|
|Garry, Daniel J; Ellington, Andrew D; Molineux, Ian J et al. (2018) Viral attenuation by engineered protein fragmentation. Virus Evol 4:vey017|
|Hendricks, Sarah A; Schweizer, Rena M; Harrigan, Ryan J et al. (2018) Natural re-colonization and admixture of wolves (Canis lupus) in the US Pacific Northwest: challenges for the protection and management of rare and endangered taxa. Heredity (Edinb) :|
|Cornejo, Omar E; Hickey, Roxana J; Suzuki, Haruo et al. (2018) Focusing the diversity of Gardnerella vaginalis through the lens of ecotypes. Evol Appl 11:312-324|
|Sheng, Haiqing; Duan, Mingrui; Hunter, Samuel S et al. (2018) High-Quality Complete Genome Sequences of Three Bovine Shiga Toxin-ProducingEscherichia coliO177:H- (fliCH25) Isolates Harboring Virulentstx2and Multiple Plasmids. Genome Announc 6:|
|Margres, Mark J; Ruiz-Aravena, Manuel; Hamede, Rodrigo et al. (2018) The Genomic Basis of Tumor Regression in Tasmanian Devils (Sarcophilus harrisii). Genome Biol Evol 10:3012-3025|
|Dorsey, Brian L; Gregory, Timothy J; Sass, Chodon et al. (2018) Pleistocene diversification in an ancient lineage: a role for glacial cycles in the evolutionary history of Dioon Lindl. (Zamiaceae). Am J Bot 105:1512-1530|
|Kravats, Andrea N; Hoskins, Joel R; Reidy, Michael et al. (2018) Functional and physical interaction between yeast Hsp90 and Hsp70. Proc Natl Acad Sci U S A 115:E2210-E2219|
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