The Center for Alaska Native Health Research (CANHR), established in 2001 with COBRE I support, has become nationally recognized for both the quality of its research to reduce disease and promote health among Alaska Native (AN) people and for Community-Based Participatory Research (CBPR) with minority populations. AN people have been engaged in all phases of CANHR research, including setting CANHR's current research agenda on obesity and metabolic disease. The evolution and solidification of this decade-long community partnership has expanded this research agenda into intervention research aimed at prevention and treatment of obesity and metabolic disease, youth suicide, and substance abuse. CANHR funding has increased from one NIH grant in 2001, to nearly $5M in 2010. With support from an NIH construction grant, we are building the first two clinical research laboratories in the state of Alaska, while increasing our net space by over 5,000 sq. ft. The University of Alaska Fairbanks leadership has increased its already substantial commitment to CANHR, further augmenting our research expertise with new faculty hires and consultation from nationally recognized senior researchers through the President's Professors program. Our publication rate continues to increase, surpassing 100 publications in the past four years. The goal of the proposed COBRE Phase III Transitional Center is to solidify these achievements with a focus on transitioning CANHR into a self-supporting, sustainable, nationally recognized research center focused on AN health and CBPR. We propose to do this by: (1) strengthening the infrastructure of core resources to support research and community engagement;(2) expanding mentoring and training opportunities to develop the next generation of AN health researchers;(3) developing an innovative Pilot Project program (External Partnerships for Specific Expertise), to foster collaborative research with scientific leaders at research-intensive institutions that, in our experience, will p9sitively impact our extramural funding success;(4) continuing the President's Professors Program to expand intellectual capital and national recognition of CANHR;and (5) including a comprehensive business plan to ensure income to sustain CANHR cores.

Public Health Relevance

A key goal of our center is to work with community partners to develop a research agenda and use the research results to better understand the causes and contributing factors of diseases faced by Alaska Native people, and their prevention and treatment. This will enhance the potential for the successful deployment of culturally respectful community-based interventions that will provide evidence-based health practices for Alaska Native people.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1)
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Liu, Yanping
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University of Alaska Fairbanks
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Lemas, Dominick J; Klimentidis, Yann C; Aslibekyan, Stella et al. (2016) Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. Mol Nutr Food Res 60:2642-2653
Fohner, Alison E; Wang, Zhican; Yracheta, Joseph et al. (2016) Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. J Nutr 146:318-25
Philip, Jacques; Ford, Tara; Henry, David et al. (2016) Relationship of Social Network to Protective Factors in Suicide and Alcohol Use Disorder Intervention for Rural Yup'ik Alaska Native Youth. Interv Psicosoc 25:45-54
O'Brien, Diane M; Thummel, Kenneth E; Bulkow, Lisa R et al. (2016) Declines in traditional marine food intake and vitamin D levels from the 1960s to present in young Alaska Native women. Public Health Nutr :1-8
Vaughan, Laura Kelly; Wiener, Howard W; Aslibekyan, Stella et al. (2015) Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup'ik) population. Metabolism 64:689-97
Fok, Carlotta Ching Ting; Henry, David; Allen, James (2015) Research Designs for Intervention Research with Small Samples II: Stepped Wedge and Interrupted Time-Series Designs. Prev Sci 16:967-77
Beaulieu-Jones, Brendin R; O'Brien, Diane M; Hopkins, Scarlett E et al. (2015) Sex, Adiposity, and Hypertension Status Modify the Inverse Effect of Marine Food Intake on Blood Pressure in Alaska Native (Yup'ik) People. J Nutr 145:931-8
Henry, David; Fok, Carlotta Ching Ting; Allen, James (2015) Why Small is Too Small a Term: Prevention Science for Health Disparities, Culturally Distinct Groups, and Community-Level Intervention. Prev Sci 16:1026-32
Ryman, Tove K; Boyer, Bert B; Hopkins, Scarlett et al. (2015) Characterising the reproducibility and reliability of dietary patterns among Yup'ik Alaska Native people. Br J Nutr 113:634-43
Trinidad, Susan Brown; Ludman, Evette J; Hopkins, Scarlett et al. (2015) Community dissemination and genetic research: moving beyond results reporting. Am J Med Genet A 167:1542-50

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