Depression is the 3rd leading contributor to the global burden of disease; alcohol and illicit drug use are among the top ten contributors to that burden (World Health Organization The Global Burden of Disease: 2004 Update). In ten years of COBRE funding, the Center for Psychiatric Neuroscience (CPN) at The University of Mississippi Medical Center (UMMC) developed cutting-edge core facilities and expanded its focus to the areas of depression and alcohol dependence. Innovative and muitidisciplinary Center investigators have collaborated in ground breaking observations on the roles of neurons and glia, cerebral vasculature, aging, gender, transcription factors, serotonin and glutamate in depression and alcoholism and many have secured independent funding. Our mission in Phase III is to continue building basic research in the pathophysiology of mental illnesses and psychoactive substance use disorders by promoting mentoring, strengthening research cores and, thereby, to increase NIH funding in Mississippi.
Specific Aims toward reaching this mission are to: 1) provide support to maintain and expand state-of-the-art research cores that are essential to support basic research across the institution and the state, 2) promote a collaborative and muitidisciplinary mentoring environment that supports innovative pilot research, and 3) develop a self-sustaining center of biomedical research excellence supported by investigator-initiated research grants and collaborative program projects. Our synergistic research cores, available across the institution and state-wide to other COBRE and INBRE investigators, will permit the development of mentored projects along a trajectory of using the Imaging Core and the Molecular and Genomics Core to quantify disease-specific pathology in tissues from the Postmortem Brain Core and modeling such pathology in the Animal Behavior Core to develop phenotypic models of psychopathology and explore novel treatments for depression and psychoactive substance use disorders, including alcohol dependence. State-of-the-art research cores will support mentored basic research in search of new strategies of prevention and treatment for these global challenges to mental health.

Public Health Relevance

Depression is a serious, persistent and potentially lethal illness affecting the mood, activity and physical health of nearly 10 million American adults per year, while 7 percent of adult Americans are alcohol dependent. A mentored basic research pilot program examining the pathophysiology of these illnesses, supported by state-of-the-art research cores, will seek new strategies of prevention and treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
4P30GM103328-04
Application #
9129778
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Program Officer
Douthard, Regine
Project Start
2013-09-30
Project End
2018-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
4
Fiscal Year
2016
Total Cost
$1,109,448
Indirect Cost
$367,342
Name
University of Mississippi Medical Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216
Fan, Yan; Chen, Ping; Raza, Muhammad U et al. (2018) Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment In Vivo and In Vitro. Neuroscience 393:123-137
Tull, Matthew T; Lee, Aaron A; Geers, Andrew L et al. (2018) Exploring the Role of Sedentary Behavior and Physical Activity in Depression and Anxiety Symptom Severity among Patients with Substance Use Disorders. Ment Health Phys Act 14:98-102
Le François, Brice; Zhang, Lei; Mahajan, Gouri J et al. (2018) A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression. J Neurosci 38:8200-8210
Turner, Paul A; Garrett, Michael R; Didion, Sean P et al. (2018) Spheroid Culture System Confers Differentiated Transcriptome Profile and Functional Advantage to 3T3-L1 Adipocytes. Ann Biomed Eng 46:772-787
Bryois, Julien; Garrett, Melanie E; Song, Lingyun et al. (2018) Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia. Nat Commun 9:3121
Mouton, Alan J; DeLeon-Pennell, Kristine Y; Rivera Gonzalez, Osvaldo J et al. (2018) Mapping macrophage polarization over the myocardial infarction time continuum. Basic Res Cardiol 113:26
Athey, Alison; Overholser, James; Bagge, Courtney et al. (2018) Risk-taking behaviors and stressors differentially predict suicidal preparation, non-fatal suicide attempts, and suicide deaths. Psychiatry Res 270:160-167
Rajkowska, Grazyna; Legutko, Beata; Moulana, Mohadetheh et al. (2018) Astrocyte pathology in the ventral prefrontal white matter in depression. J Psychiatr Res 102:150-158
Samara, Zoe; Evers, Elisabeth A T; Peeters, Frenk et al. (2018) Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease. Biol Psychiatry Cogn Neurosci Neuroimaging 3:348-357
Spann, Redin A; Lawson, William J; Bidwell 3rd, Gene L et al. (2018) Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development. Clin Sci (Lond) 132:295-312

Showing the most recent 10 out of 65 publications