The Mass Spectrometry Core Facility provides support to enable traditional and non-traditional users of mass spectrometry the ability to apply advanced mass spectrometry analysis of small molecules to achieve their research objectives. The major focus of this Core is small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. According to the Network of IDeA Funded Core Laboratories database, out of 63 mass spectrometry core facilities listed, only seven (7) provide small molecule analysis service, and just four (4) allow for lipidomic analysis. The relative uniqueness of our small molecule mass spectrometry analysis of small molecules has resulted in a recent surge in demand for our services, a dramatic increase in the publication of manuscripts, and an increase in submission and receipt of funded grants. The major roles of this Mass Spectrometry Core Facility are to: (1) Provide a facility for the use of established methods of mass spectroscopic analysis of small molecules;(2) Actively develop new mass spectrometry approaches for small molecule analysis, as well as data collection and analysis;(3) Continuously expand our capacity and capabilities to support new research projects;(4) Provide advanced training in mass spectrometry especially to graduate students;(5) Assist with new faculty hiring;and (6) Aid off-campus investigators with similar analyses. The operation of this Core is based on approved policies posted on the Core's website that regulate services provided, access to the instruments, training, quality control, cost, and conflict resolution. Currently, we are providing two major types of services: (1.) Full service where Core personnel perform the analyses and train investigators for sample extraction and preparation;and (2.) Self service where Core personnel train investigators to perform their own sample extraction, preparation and analysis. Our advisory board provides input on these policies and activities. COBRE Phase III support of the Mass Spectrometry Core Facility will enable us to support existing and future research projects, will enhance our sustainability, and will significantly facilitate the development of biomedical research in the Central Region and beyond.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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University of North Dakota
Grand Forks
United States
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Soliman, Mahmoud L; Geiger, Jonathan D; Chen, Xuesong (2017) Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. J Neuroimmune Pharmacol 12:163-170
Martin, Gregory G; Landrock, Danilo; Chung, Sarah et al. (2017) Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids. J Neurochem 140:294-306
Pu, Qinqin; Gan, Changpei; Li, Rongpeng et al. (2017) Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis. J Immunol 198:3205-3213
Ye, Yan; Lin, Ping; Zhang, Weidong et al. (2017) DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. J Immunol 198:2844-2853
Sharma, Atul; Simonson, Tanner J; Jondle, Christopher N et al. (2017) Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy. J Infect Dis 215:1040-1048
Vacano, Guido N; Gibson, David S; Turjoman, Abdullah Arif et al. (2017) Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Neurobiol Aging 63:96-109
Carlson, Edward C; Chhoun, Jennifer M; Grove, Bryon D et al. (2017) Renoprotection From Diabetic Complications in OVE Transgenic Mice by Endothelial Cell Specific Overexpression of Metallothionein: A TEM Stereological Analysis. Anat Rec (Hoboken) 300:560-576
Puig, Kendra L; Brose, Stephen A; Zhou, Xudong et al. (2017) Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. Sci Rep 7:43725
Sun, Yuyang; Zhang, Haopeng; Selvaraj, Senthil et al. (2017) Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons. J Neurosci 37:3364-3377
Krout, Danielle; Rodriquez, Meghan; Brose, Stephen A et al. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8:1011-1018

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