Over the past 9 years of COBRE grant support, the Edward C. Carlson Imaging and Image Analysis Core Facility has become an important research resource that supports the microscopic imaging and image analysis requirements of our COBRE grant supported neurodegenerative disease research group as well as other investigators. The Core maintains and provides access to fluorescence, confocal, multiphoton intravital and electron microscopy instrumentation, assists investigators in the design of experiments, develops new applications, and trains investigators in microscopic methods and use of the equipment, and provides core users with information resources related to microscopic imaging. Equipment housed in the Core includes two confocal microscopes, a multiphoton/visible confocal intravital microscope, two fluorescence microscopes, two electron microscopes, and a range of ancillary microscopy equipment. Acquisition of new sophisticated confocal and multiphoton equipment, maintenance of service contracts, support for staff positions, and increased training of investigators in the use of our imaging and image analysis equipment has provided investigators with the ability to employ a range of imaging applications that were not available prior to the COBRE program. The number of publications arising from work performed in the Core has increased to the point where approximately 1/3 of the publications arising from the basic science departments include data collected in the Imaging Core Facility. Moreover, investigators from other parts of campus including the Departments of Biology, Chemistry, and Chemical Engineering as well as from the Energy and Environmental Research Center on the UND campus use the facility. Projects conducted in the Imaging Core Facility investigate a broad range of biomedical issues including protein distribution and expression in cells and tissues, protein-protein interactions, membrane receptor and transporter distribution and function, and cellular and tissue changes as hallmarks of disease pathogenesis. Continued support of this Core will be critical to growing our research enterprise, and will allow the Core to become a sustainable resource that supports research campus-wide as well as elsewhere in the region.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103329-02
Application #
8510678
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$207,626
Indirect Cost
$57,172
Name
University of North Dakota
Department
Type
DUNS #
102280781
City
Grand Forks
State
ND
Country
United States
Zip Code
58202
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Sun, Yuyang; Zhang, Haopeng; Selvaraj, Senthil et al. (2017) Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons. J Neurosci 37:3364-3377
Krout, Danielle; Rodriquez, Meghan; Brose, Stephen A et al. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8:1011-1018

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