Since our neurodegerative disease research group received COBRE grant support we have administered 5 separate research pilot grant programs and provided financial support to investigators totaling in excess of $1,000,000. The purpose of the pilot grant program has been to increase the scope of research conducted at UND related to the theme of the COBRE grant and to increase the competitiveness of UND investigators for funding from extramural organizations. Resulting from this investment in research pilot grant support, the recipients brought into the institution over $5.2M. Thus, pilot grants have been an excellent investment in the on going success of our COBRE grant supported neurodegenerative disease research group. The following is a brief description of the research pilot grant program that we are proposing for the COBRE Phase III funding period. First, we will solicit proposals for our research pilot grant program. Second, the applications will be submitted electronically to the PI/PD. Third, the grants will be distributed to the grant review committee consisting of Dr. Geiger (PI/PD), Drs. Vaughan and Brown-Borg of our Internal Advisory Committee, and Dr. Fyffe of our External Advisory Board. Fourth, the reviewers will meet with the applicants to discuss the hypothesis proposed, the methodological and scientific approaches to be taken, the respective involvement of named investigators, and their timelines and benchmarks of success. We have found that this;""""""""site visit"""""""" approach provides to the applicants a very high quality review and an outstanding opportunity for mentorship. Fifth, midway through the pilot grant year investigators will submit a progress report and then again meet with the grant review committee to evaluate progress, receive advice, and review plans for the remaining one-half of the pilot grant year. At the end of the pilot grant period, the investigators will submit to the review committee a final report in which they describe their original or modified specific aims, their research findings, and most importantly detailed information about abstracts submitted and presented, manuscripts submitted and published, and grants submitted and funded.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Dakota
Grand Forks
United States
Zip Code
Brose, Stephen A; Golovko, Svetlana A; Golovko, Mikhail Y (2016) Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation. Lipids 51:487-95
Selvaraj, Senthil; Sun, Yuyang; Sukumaran, Pramod et al. (2016) Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway. Mol Carcinog 55:818-31
Schott, Micah B; Gonowolo, Faith; Maliske, Benjamin et al. (2016) FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca(2+)/PKA crosstalk. Cell Signal 28:294-306
Martin, Gregory G; Chung, Sarah; Landrock, Danilo et al. (2016) FABP-1 gene ablation impacts brain endocannabinoid system in male mice. J Neurochem 138:407-22
Carballeira, Néstor M; Montano, Nashbly; Amador, Luis A et al. (2016) Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB. Lipids 51:245-56
Soliman, Mahmoud L; Geiger, Jonathan D; Chen, Xuesong (2016) Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. J Neuroimmune Pharmacol :
Ackermann, Karly L; Florke, Rebecca R; Reyes, Shannon S et al. (2016) TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region. J Biol Chem 291:23604-23617
Zhuang, Yan; Li, Yi; Li, Xuefeng et al. (2016) Atg7 Knockdown Augments Concanavalin A-Induced Acute Hepatitis through an ROS-Mediated p38/MAPK Pathway. PLoS One 11:e0149754
Chen, Xuesong; Wagener, John F; Ghribi, Othman et al. (2016) Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci 8:129
Zhang, Shuang; Wu, Min; Gao, Hongwei (2015) Editorial: NFAT signaling: no FAT as new weapon to fight shock. J Leukoc Biol 97:997-9

Showing the most recent 10 out of 60 publications