Since our neurodegerative disease research group received COBRE grant support we have administered 5 separate research pilot grant programs and provided financial support to investigators totaling in excess of $1,000,000. The purpose of the pilot grant program has been to increase the scope of research conducted at UND related to the theme of the COBRE grant and to increase the competitiveness of UND investigators for funding from extramural organizations. Resulting from this investment in research pilot grant support, the recipients brought into the institution over $5.2M. Thus, pilot grants have been an excellent investment in the on going success of our COBRE grant supported neurodegenerative disease research group. The following is a brief description of the research pilot grant program that we are proposing for the COBRE Phase III funding period. First, we will solicit proposals for our research pilot grant program. Second, the applications will be submitted electronically to the PI/PD. Third, the grants will be distributed to the grant review committee consisting of Dr. Geiger (PI/PD), Drs. Vaughan and Brown-Borg of our Internal Advisory Committee, and Dr. Fyffe of our External Advisory Board. Fourth, the reviewers will meet with the applicants to discuss the hypothesis proposed, the methodological and scientific approaches to be taken, the respective involvement of named investigators, and their timelines and benchmarks of success. We have found that this;""""""""site visit"""""""" approach provides to the applicants a very high quality review and an outstanding opportunity for mentorship. Fifth, midway through the pilot grant year investigators will submit a progress report and then again meet with the grant review committee to evaluate progress, receive advice, and review plans for the remaining one-half of the pilot grant year. At the end of the pilot grant period, the investigators will submit to the review committee a final report in which they describe their original or modified specific aims, their research findings, and most importantly detailed information about abstracts submitted and presented, manuscripts submitted and published, and grants submitted and funded.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103329-03
Application #
8685288
Study Section
Special Emphasis Panel (ZRR1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Dakota
Department
Type
DUNS #
City
Grand Forks
State
ND
Country
United States
Zip Code
58202
Soliman, Mahmoud L; Geiger, Jonathan D; Chen, Xuesong (2017) Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation. J Neuroimmune Pharmacol 12:163-170
Martin, Gregory G; Landrock, Danilo; Chung, Sarah et al. (2017) Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids. J Neurochem 140:294-306
Pu, Qinqin; Gan, Changpei; Li, Rongpeng et al. (2017) Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis. J Immunol 198:3205-3213
Ye, Yan; Lin, Ping; Zhang, Weidong et al. (2017) DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. J Immunol 198:2844-2853
Sharma, Atul; Simonson, Tanner J; Jondle, Christopher N et al. (2017) Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy. J Infect Dis 215:1040-1048
Vacano, Guido N; Gibson, David S; Turjoman, Abdullah Arif et al. (2017) Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Neurobiol Aging 63:96-109
Carlson, Edward C; Chhoun, Jennifer M; Grove, Bryon D et al. (2017) Renoprotection From Diabetic Complications in OVE Transgenic Mice by Endothelial Cell Specific Overexpression of Metallothionein: A TEM Stereological Analysis. Anat Rec (Hoboken) 300:560-576
Puig, Kendra L; Brose, Stephen A; Zhou, Xudong et al. (2017) Amyloid precursor protein modulates macrophage phenotype and diet-dependent weight gain. Sci Rep 7:43725
Sun, Yuyang; Zhang, Haopeng; Selvaraj, Senthil et al. (2017) Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons. J Neurosci 37:3364-3377
Krout, Danielle; Rodriquez, Meghan; Brose, Stephen A et al. (2017) Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS Chem Neurosci 8:1011-1018

Showing the most recent 10 out of 77 publications