The Core Synthesis Facility was established in 2007 to provide state-of-the-art capabilities in synthetic organic chemistry to biomedical researchers in the State of North Dakota and beyond. The core has served a wide variety of research projects in multiple disciplines on the campus and throughout the region. Its services include equipment and expertise to conduct synthetic organic chemistry and providing access to small organic compounds, potential drug molecules, and labeled molecules for biomedical studies. The core has received institutional support by way of salary and benefit contributions of 50% for the manager. Dr. Yonghua Yang, as well as the COBRE Administrative Assistant who coordinates activities between the cores. The core is expected to be an important part of the growth and development of NDSU as a recruiting tool to attract new biomedical scientists, as a cost-effective measure to stretch federal research dollars, and as a means of teaching and training investigators in chemical techniques. Outreach to educational collectives has broadened the impact of the core on science in the region.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
North Dakota State University
United States
Zip Code
Ambhore, Nilesh Sudhakar; Katragadda, Rathnavali; Raju Kalidhindi, Rama Satyanarayana et al. (2018) Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation. Mol Cell Endocrinol 476:37-47
Mohammad, Jiyan; Dhillon, Harsharan; Chikara, Shireen et al. (2018) Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models. Oncotarget 9:10457-10469
Froberg, James; Choi, Woo-Sik; Sedigh, Abbas et al. (2018) Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates. Chem Commun (Camb) 54:10248-10251
Lundquist, Taylor A; Kittilson, Jeffrey D; Ahsan, Rubina et al. (2018) The effect of within-instar development on tracheal diameter and hypoxia-inducible factors ? and ? in the tobacco hornworm, Manduca sexta. J Insect Physiol 106:199-208
Chikara, Shireen; Mamidi, Sujan; Sreedasyam, Avinash et al. (2018) Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer Prev Res (Phila) 11:27-37
Jensen, Jaime L; Wu, Qiong; Colbert, Christopher L (2018) NMR assignments of the N-terminal signaling domain of the TonB-dependent outer membrane transducer PupB. Biomol NMR Assign 12:91-94
Karandish, Fataneh; Froberg, James; Borowicz, Pawel et al. (2018) Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors. Colloids Surf B Biointerfaces 163:225-235
You, Seungyong; Froberg, James; Yu, Junru et al. (2017) Real-time monitoring of conformational transitions of single-molecule histone deacetylase 8 with nanocircuits. Chem Commun (Camb) 53:3307-3310
Vasam, Goutham; Joshi, Shrinidh; Thatcher, Sean E et al. (2017) Reversal of Bone Marrow Mobilopathy and Enhanced Vascular Repair by Angiotensin-(1-7) in Diabetes. Diabetes 66:505-518
Eklund, Bridget E; Mahdi, Osama; Huntley, Jason F et al. (2017) The orange spotted cockroach (Blaptica dubia, Serville 1839) is a permissive experimental host forFrancisella tularensis. Proc W Va Acad Sci 89:34-47

Showing the most recent 10 out of 90 publications