We propose to build on the successes of our of past COBRE phase I and II grants to create a collection of three research cores that, coupled with a pilot project mechanism, will provide us with the resources to develop a strong team of investigators to study the prevention and treatment of osteoarthritis. Ours is a multidisciplinary, multi-scale approach to the study of osteoarthritis (OA), involving faculty doing work in extracellular matrix proteins, biomechanical modeling of joint forces, and clinical studies. The uniqueness of our approach will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, and rehabilitation. We will build on the distinctive organization of the center established with the COBRE award and the collaborative projects described in this application. Three core resources will be run through this award: (1) A cytomechanics core, first established in our phase II grant, will be strengthened to provide tools for orthopaedic researchers to study how bone, cartilage and ligament respond to stress and strain. This involves tools for bioimaging and micromechanical testing. (2) A patient specific modeling (PSM) core will be established. This is a modification and expansion of the motion analysis core established in our COBRE I award. It will provide a means to determine differences in tissue forces associated with pathologies and will also be used to determine biomechanical differences associated with various treatment paths, which may impact the development of osteoarthritis. (3) A clinical research core (the ResCore) will be established for the first time to aid us as we expand our clinical trials. It will provide patient database access and biostatistics support for al projects. In addition, we will continue to maintain our mentoring mechanism. Faculty development is key to our success and we will continue to mentor our faculty and work with our External Advisory Committee to provide very regular feedback to COBRE investigators about their research. Our goal is to use these resources to establish a large base of NIH R01 funded investigators studying osteoarthritis and, by those R01 grants, be able to support our cores in the future and greatly expand our efforts to make strong progress in understanding the prevention and treatment of OA.

Public Health Relevance

(provided by applicant): Osteoarthritis (OA) is a major disease that affects 27 million Americans. The goal of our work is to develop better ways to improve the prevention and treatment of osteoarthritis. Ours is a translational approach that uses patient specific medicine to provide personalized treatment that will improve patient outcomes.
Our aims are also to grow a cadre of investigators who can form a multi-disciplinary team of OA researchers.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Douthard, Regine
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Delaware
Biomedical Engineering
Schools of Engineering
United States
Zip Code
Awad, Louis N; Palmer, Jacqueline A; Pohlig, Ryan T et al. (2015) Walking speed and step length asymmetry modify the energy cost of walking after stroke. Neurorehabil Neural Repair 29:416-23
Suydam, Stephen M; Buchanan, Thomas S; Manal, Kurt et al. (2015) Compensatory muscle activation caused by tendon lengthening post-Achilles tendon rupture. Knee Surg Sports Traumatol Arthrosc 23:868-74
Kao, Pei-Chun; Dingwell, Jonathan B; Higginson, Jill S et al. (2014) Dynamic instability during post-stroke hemiparetic walking. Gait Posture 40:457-63
Stanhope, Victoria A; Knarr, Brian A; Reisman, Darcy S et al. (2014) Frontal plane compensatory strategies associated with self-selected walking speed in individuals post-stroke. Clin Biomech (Bristol, Avon) 29:518-22
Lai, Xiaohan; Price, Christopher; Lu, Xin Lucas et al. (2014) Imaging and quantifying solute transport across periosteum: implications for muscle-bone crosstalk. Bone 66:82-9
Wang, Bin; Lai, Xiaohan; Price, Christopher et al. (2014) Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res 29:878-91
Gardinier, Emily S; Manal, Kurt; Buchanan, Thomas S et al. (2014) Clinically-relevant measures associated with altered contact forces in patients with anterior cruciate ligament deficiency. Clin Biomech (Bristol, Avon) 29:531-6
Suydam, Stephen M; Buchanan, Thomas S (2014) Is echogenicity a viable metric for evaluating tendon properties in vivo? J Biomech 47:1806-9
Logerstedt, David; Di Stasi, Stephanie; Grindem, Hege et al. (2014) Self-reported knee function can identify athletes who fail return-to-activity criteria up to 1 year after anterior cruciate ligament reconstruction: a delaware-oslo ACL cohort study. J Orthop Sports Phys Ther 44:914-23
Gardinier, Emily S; Manal, Kurt; Buchanan, Thomas S et al. (2013) Minimum detectable change for knee joint contact force estimates using an EMG-driven model. Gait Posture 38:1051-3