The Clinical Research Core will promote excellence in research for all human subjects research and provide support to all COBRE III investigators as needed. Comprehensive support services will be available through this core for all aspects of participant recruitment, regulatory submissions, study coordination, compliance, reporting of adverse events, data management and biostatistical support. The Clinical Research Core will play a central role for all COBRE III research and will promote focused and efficient interactions among studies resulting in a well-integrated center that is greater than the sum of its individual parts.
The specific aims of the Clinical Research Core are to provide: 1. Support to optimize the recruitment and retention of participants for studies of osteoarthritis prevention and treatment 2. Support for management of all data resources. Direct support for design of data collection forms, as well as data entry and management, will be provided to research investigators 3. Support for biostatistical needs. Biostatisticians will provide consultation regarding statistical analysis, as well as grant and manuscript preparation. In the case of pilot studies, support will also be available for research design and estimation of sample sizes. The Clinical Research Core will be under the direction of Dr. Lynn Snyder-Mackler (Director of the Clinical Research Core). Dr. Snyder-Mackler, working with Dr. Kurt Manal (COBRE III Program Coordinator), will provide overall administrative direction and coordination of the Clinical Research Core. Or. Snyder-Mackler has worked closely with Dr. Buchanan, the COBRE Director, in the planning of the overall structure of the COBRE III and has specifically worked with the individual project Pi's in the planning of their respective research projects involving human subjects. Dr. Snyder-Mackler will provide oversight of the Clinical Research Core's staff, including the Research Coordinators, Data Managers and Biostatisticians. Given the nature of the work to be done by the Clinical Research Core, formal communication processes will be required. The plan will be for Dr. Snyder-Mackler to meet with all members of the core on a biweekly basis to discuss ongoing studies, as well as potential pilot projects which will require core services. All Clinical Research Core members will also be encouraged to participate in all meetings of the COBRE III program, as appropriate. The Clinical Research Core will serve all projects, as well as the pilot projects. The Clinical Research Core will be directly involved in participant recruitment/retention efforts, data management and biostatistical consultation. Depending on the nature of the pilot studies that are funded through the COBRE III, appropriate support in the areas of recruitment, data management and biostatistical consultation will be available, particularly in the realm of research design and sample size estimation. In all, the coordination of clinical research support services in the context of this Clinical Research Core will be a vital component of the COBRE III program here at the University of Delaware. This Core will ensure efficient use of shared resources and maximize productivity of investigators to carryout ongoing studies and to develop new research questions into competitive grant proposals.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103333-02
Application #
8518413
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$210,281
Indirect Cost
$87,007
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Awad, Louis N; Reisman, Darcy S; Pohlig, Ryan T et al. (2016) Identifying candidates for targeted gait rehabilitation after stroke: better prediction through biomechanics-informed characterization. J Neuroeng Rehabil 13:84
Awad, Louis N; Reisman, Darcy S; Pohlig, Ryan T et al. (2016) Reducing The Cost of Transport and Increasing Walking Distance After Stroke: A Randomized Controlled Trial on Fast Locomotor Training Combined With Functional Electrical Stimulation. Neurorehabil Neural Repair 30:661-70
Fan, Lixia; Pei, Shaopeng; Lucas Lu, X et al. (2016) A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone. Bone Res 4:16032
Knarr, Brian A; Higginson, Jill S; Zeni, Joseph A (2016) Change in knee contact force with simulated change in body weight. Comput Methods Biomech Biomed Engin 19:320-323
Wellsandt, Elizabeth; Gardinier, Emily S; Manal, Kurt et al. (2016) Decreased Knee Joint Loading Associated With Early Knee Osteoarthritis After Anterior Cruciate Ligament Injury. Am J Sports Med 44:143-51
Capin, Jacob J; Khandha, Ashutosh; Zarzycki, Ryan et al. (2016) Gait mechanics and second ACL rupture: Implications for delaying return-to-sport. J Orthop Res :
Zellers, Jennifer A; Cortes, Daniel H; Silbernage L, Karin Grävare (2016) FROM ACUTE ACHILLES TENDON RUPTURE TO RETURN TO PLAY - A CASE REPORT EVALUATING RECOVERY OF TENDON STRUCTURE, MECHANICAL PROPERTIES, CLINICAL AND FUNCTIONAL OUTCOMES. Int J Sports Phys Ther 11:1150-1159
Palmer, Jacqueline A; Needle, Alan R; Pohlig, Ryan T et al. (2016) Atypical cortical drive during activation of the paretic and nonparetic tibialis anterior is related to gait deficits in chronic stroke. Clin Neurophysiol 127:716-23
Khandha, Ashutosh; Manal, Kurt; Wellsandt, Elizabeth et al. (2016) Gait mechanics in those with/without medial compartment knee osteoarthritis five years after anterior cruciate ligament reconstruction. J Orthop Res :
Srinivasan, Padma P; Parajuli, Ashutosh; Price, Christopher et al. (2015) Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes. PLoS One 10:e0127290

Showing the most recent 10 out of 45 publications