The Cytomechanics Core is designed to support the University of Delaware's concerted multi-disciplinary focus on the study of osteoarthritis (OA), a major public health concern. Aside from the large socioeconomic burden, the pain and disability associated with OA greatly impacts the quality life of patients. The development of OA involves multiple factors including age, genetics, and mechanical factors. During phases I and II of the UD COBRE program, we have made great strides in understanding the role of mechanical forces in OA development and treatment of this pathology at the molecular, cellular, tissue, joint, and whole body levels. Cytomechanics is fundamental for normal cell and tissue function and disease development. The cell, the universal basic unit of life, behaves as a "mechanical living" entity. In addition to sense of "smell" or "taste" mediated by chemical reactions, cells also display a strong sense of "touch" mediated by mechanical interactions. Thus, the mechanical environment drives many fundamental processes such as cell shape, mobility, growth, differentiation, and cell fate determination. In OA, many important remain unanswered, such as (1) how mechanical forces are transduced from systemic locomotion and physical activity to local tissue and cellular stresses, (2) how cells in healthy or diseased native joint tissues respond and adapt to the mechanical environment, (3) how to use our knowledge of tissue and cell mechanics to design pharmaceutical interventions or rehabilitation protocols to treat OA, (4) how to achieve real-time and closed-loop control of cell and tissue mechanics and behavior during tissue engineering. To meet these scientific needs, we have designed this Cytomechanics Core with state-of-the-art imaging techniques and precise mechanical manipulation tools that have been acquired during previous COBRE funding years and will continue to be built upon by our COBRE team.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103333-03
Application #
8688273
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$171,726
Indirect Cost
$59,487
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Awad, Louis N; Palmer, Jacqueline A; Pohlig, Ryan T et al. (2015) Walking speed and step length asymmetry modify the energy cost of walking after stroke. Neurorehabil Neural Repair 29:416-23
Suydam, Stephen M; Buchanan, Thomas S; Manal, Kurt et al. (2015) Compensatory muscle activation caused by tendon lengthening post-Achilles tendon rupture. Knee Surg Sports Traumatol Arthrosc 23:868-74
Kao, Pei-Chun; Dingwell, Jonathan B; Higginson, Jill S et al. (2014) Dynamic instability during post-stroke hemiparetic walking. Gait Posture 40:457-63
Stanhope, Victoria A; Knarr, Brian A; Reisman, Darcy S et al. (2014) Frontal plane compensatory strategies associated with self-selected walking speed in individuals post-stroke. Clin Biomech (Bristol, Avon) 29:518-22
Lai, Xiaohan; Price, Christopher; Lu, Xin Lucas et al. (2014) Imaging and quantifying solute transport across periosteum: implications for muscle-bone crosstalk. Bone 66:82-9
Wang, Bin; Lai, Xiaohan; Price, Christopher et al. (2014) Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res 29:878-91
Gardinier, Emily S; Manal, Kurt; Buchanan, Thomas S et al. (2014) Clinically-relevant measures associated with altered contact forces in patients with anterior cruciate ligament deficiency. Clin Biomech (Bristol, Avon) 29:531-6
Suydam, Stephen M; Buchanan, Thomas S (2014) Is echogenicity a viable metric for evaluating tendon properties in vivo? J Biomech 47:1806-9
Logerstedt, David; Di Stasi, Stephanie; Grindem, Hege et al. (2014) Self-reported knee function can identify athletes who fail return-to-activity criteria up to 1 year after anterior cruciate ligament reconstruction: a delaware-oslo ACL cohort study. J Orthop Sports Phys Ther 44:914-23
Gardinier, Emily S; Manal, Kurt; Buchanan, Thomas S et al. (2013) Minimum detectable change for knee joint contact force estimates using an EMG-driven model. Gait Posture 38:1051-3