The Cytomechanics Core is designed to support the University of Delaware's concerted multi-disciplinary focus on the study of osteoarthritis (OA), a major public health concern. Aside from the large socioeconomic burden, the pain and disability associated with OA greatly impacts the quality life of patients. The development of OA involves multiple factors including age, genetics, and mechanical factors. During phases I and II of the UD COBRE program, we have made great strides in understanding the role of mechanical forces in OA development and treatment of this pathology at the molecular, cellular, tissue, joint, and whole body levels. Cytomechanics is fundamental for normal cell and tissue function and disease development. The cell, the universal basic unit of life, behaves as a "mechanical living" entity. In addition to sense of "smell" or "taste" mediated by chemical reactions, cells also display a strong sense of "touch" mediated by mechanical interactions. Thus, the mechanical environment drives many fundamental processes such as cell shape, mobility, growth, differentiation, and cell fate determination. In OA, many important remain unanswered, such as (1) how mechanical forces are transduced from systemic locomotion and physical activity to local tissue and cellular stresses, (2) how cells in healthy or diseased native joint tissues respond and adapt to the mechanical environment, (3) how to use our knowledge of tissue and cell mechanics to design pharmaceutical interventions or rehabilitation protocols to treat OA, (4) how to achieve real-time and closed-loop control of cell and tissue mechanics and behavior during tissue engineering. To meet these scientific needs, we have designed this Cytomechanics Core with state-of-the-art imaging techniques and precise mechanical manipulation tools that have been acquired during previous COBRE funding years and will continue to be built upon by our COBRE team.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103333-03
Application #
8688273
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$171,726
Indirect Cost
$59,487
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Awad, Louis N; Reisman, Darcy S; Pohlig, Ryan T et al. (2016) Identifying candidates for targeted gait rehabilitation after stroke: better prediction through biomechanics-informed characterization. J Neuroeng Rehabil 13:84
Awad, Louis N; Reisman, Darcy S; Pohlig, Ryan T et al. (2016) Reducing The Cost of Transport and Increasing Walking Distance After Stroke: A Randomized Controlled Trial on Fast Locomotor Training Combined With Functional Electrical Stimulation. Neurorehabil Neural Repair 30:661-70
Fan, Lixia; Pei, Shaopeng; Lucas Lu, X et al. (2016) A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone. Bone Res 4:16032
Knarr, Brian A; Higginson, Jill S; Zeni, Joseph A (2016) Change in knee contact force with simulated change in body weight. Comput Methods Biomech Biomed Engin 19:320-323
Wellsandt, Elizabeth; Gardinier, Emily S; Manal, Kurt et al. (2016) Decreased Knee Joint Loading Associated With Early Knee Osteoarthritis After Anterior Cruciate Ligament Injury. Am J Sports Med 44:143-51
Capin, Jacob J; Khandha, Ashutosh; Zarzycki, Ryan et al. (2016) Gait mechanics and second ACL rupture: Implications for delaying return-to-sport. J Orthop Res :
Zellers, Jennifer A; Cortes, Daniel H; Silbernage L, Karin Grävare (2016) FROM ACUTE ACHILLES TENDON RUPTURE TO RETURN TO PLAY - A CASE REPORT EVALUATING RECOVERY OF TENDON STRUCTURE, MECHANICAL PROPERTIES, CLINICAL AND FUNCTIONAL OUTCOMES. Int J Sports Phys Ther 11:1150-1159
Palmer, Jacqueline A; Needle, Alan R; Pohlig, Ryan T et al. (2016) Atypical cortical drive during activation of the paretic and nonparetic tibialis anterior is related to gait deficits in chronic stroke. Clin Neurophysiol 127:716-23
Khandha, Ashutosh; Manal, Kurt; Wellsandt, Elizabeth et al. (2016) Gait mechanics in those with/without medial compartment knee osteoarthritis five years after anterior cruciate ligament reconstruction. J Orthop Res :
Srinivasan, Padma P; Parajuli, Ashutosh; Price, Christopher et al. (2015) Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes. PLoS One 10:e0127290

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