The overall goal of the proposed COBRE is to expand and develop the research capabilities and infrastructure for University of Delaware faculty in order to enable excellent multidisciplinary, collaborative research to address mechanisms of OA as well as its prevention and treatment. This approach is multi-scale in nature addressing the problem from a cellular level (Cythomechanics Core) to a larger system's scale focusing on muscle &joint function (Patient-Specific Modeling Core). There are many faculty at our institution conducting biomedical research investigating muscle and joint function in people with pathology, including OA. The majority of these researchers have expertise in specific data collection methodologies and analyses involving video-based motion capture, muscle strength testing, FES, EMG and medical imaging. Despite a broad-base of expertise, faculty tend to work, collect and analyze data in isolation. With this distributed approach it is difficult to share our collective knowledge and advance the capabilities of patient specific biomechanical modeling. The importance of making advanced tools for integrative biomechanical analyses available to clinicians (and researchers) was recently recognized by a summit panel of leading biomedical scientists (Ateshian &Friedman, 2009). This is exactly the purpose of our Core facility. The Patient-Specific Modeling Core (PSM Core) will provide researchers and clinicians state-of-the- art data acquisition and computational tools that will allow them to pose research questions they might not have been able to ask otherwise. This will advance our understanding of OA mechanisms, prevention and treatment. The PSM Core will be built around existing laboratory space and major equipment obtained with funds from COBRE I &II award. The PSM Core will be co-directed by Drs. Jill Higginson and Kurt Manal, both of whom are faculty in the Department of Mechanical Engineering and have significant experience developing, using and managing the hardware and software tools supported by the core. The objectives of the PSM Core are to develop, maintain and support integrated methodologies and computational tools in which patient specific musculoskeletal architecture, neuromuscular control and movement patterns will be measured and modeled in a uniform and structured manner. Importantly, knowledge will be shared with investigators, students and the biomechanics community through training and outreach activities. Modeling and simulation results will be coupled with clinically meaningful output parameters to determine effectiveness of targeted interventions, and will be customized to provide subject-specific responses which may help drive future intervention approaches. The following specific aims will be achieved: 1. Enhance functionality and compatibility of existing and novel tools (motion capture, imaging and modeling) to streamline data collection and processing to extract clinically useful measures. 2. Develop and apply musculoskeletal modeling and simulation tools for COBRE projects which provide insight to muscle coordination, task specific function and tissue loading 3. Share modeling approaches to OA and clinical outcomes with the local and global community through workshops and web-based resources. With the resources made available through the PSM Core, we will assist with all aspects of motion capture and imaging acquisition including development of data processing algorithms. Our mission is to help individual COBRE project PIs address specific aims related to joint kinematics and kinetics, neuromuscular activation and timing, muscle and joint contact forces, muscle contributions to movement and coordination, and other parameters according to the needs of individual research projects. The PSM Core personnel will work closely with individual PIs to ensure that the targeted specific aims will be adequately addressed by the available methodologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103333-03
Application #
8688274
Study Section
Special Emphasis Panel (ZRR1-RI-B)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$389,001
Indirect Cost
$134,752
Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716
Wang, Bin; Sun, Xuanhao; Akkus, Ozan et al. (2017) Elevated solute transport at sites of diffuse matrix damage in cortical bone: Implications on bone repair. J Orthop Res :
Wellsandt, Elizabeth; Failla, Mathew J; Snyder-Mackler, Lynn (2017) Limb Symmetry Indexes Can Overestimate Knee Function After Anterior Cruciate Ligament Injury. J Orthop Sports Phys Ther 47:334-338
Nawasreh, Zakariya; Logerstedt, David; Cummer, Kathleen et al. (2017) Functional performance 6 months after ACL reconstruction can predict return to participation in the same preinjury activity level 12 and 24 months after surgery. Br J Sports Med :
Capin, Jacob J; Behrns, William; Thatcher, Karen et al. (2017) On-Ice Return-to-Hockey Progression After Anterior Cruciate Ligament Reconstruction. J Orthop Sports Phys Ther 47:324-333
Richardson, R Tyler; Rapp, Elizabeth A; Quinton, R Garry et al. (2017) Errors Associated With Utilizing Prescribed Scapular Kinematics to Estimate Unconstrained, Natural Upper Extremity Motion in Musculoskeletal Modeling. J Appl Biomech 33:469-473
Wellsandt, Elizabeth; Khandha, Ashutosh; Manal, Kurt et al. (2017) Predictors of knee joint loading after anterior cruciate ligament reconstruction. J Orthop Res 35:651-656
Khandha, Ashutosh; Manal, Kurt; Wellsandt, Elizabeth et al. (2017) Gait mechanics in those with/without medial compartment knee osteoarthritis 5 years after anterior cruciate ligament reconstruction. J Orthop Res 35:625-633
Wellsandt, E; Zeni, J A; Axe, M J et al. (2017) Hip joint biomechanics in those with and without post-traumatic knee osteoarthritis after anterior cruciate ligament injury. Clin Biomech (Bristol, Avon) 50:63-69
Nawasreh, Zakariya; Logerstedt, David; Cummer, Kathleen et al. (2017) Do Patients Failing Return-to-Activity Criteria at 6 Months After Anterior Cruciate Ligament Reconstruction Continue Demonstrating Deficits at 2 Years? Am J Sports Med 45:1037-1048
Capin, Jacob J; Khandha, Ashutosh; Zarzycki, Ryan et al. (2017) Gait mechanics and second ACL rupture: Implications for delaying return-to-sport. J Orthop Res 35:1894-1901

Showing the most recent 10 out of 55 publications