The Administrative Core of the Phase 111 COBRE application seeks to offer scientific oversight, leadership, and centralized administrative services for the University of South Carolina's biomedical research community by providing central core facilities to researchers across departments and colleges, as well as to the greater research community statewide. The Core's centralized administrative services and research core management generates significant efficiencies for both staffing and operations for all its core facilities and affiliated investigators. The Core's administrative services include: fiscal management of affiliated accounts, day-to-day operations, expert pre-award assistance (including budget development and proposal assembly and submission), and post-award grants administration to all affiliated faculty. This Core has expanded its services to include community engagement and resource development, along with being active in the recruitment of new CCCR members, facilitating intra-institutional collaborations, and organizing the CCCR's annual meeting. The Administrative Core continually evaluates its services through the ongoing consultation and evaluation by the Internal Steering Committee, the Director/PI, and the External Advisory Committee. To carry out these efforts, this Core will carry out the following aims during Phase 111: Provide central management of grant administration services, coordination of community engagement initiatives and resource development efforts. The Core provides centralized services and has developed infrastructure that fully optimizes grant administration, community engagement, and resource development services on behalf of the Center's core facilities and member investigators. Provide scientific leadership, organizational management, and ongoing evaluation of the Research Cores. It is the responsibility of the Core to provide continued research training and financial support to investigators to best facilitate their proposed research, along with implementing new research technology and overseeing the training of investigators who utilize the Center-supported cores.

Public Health Relevance

Colorectal cancer is diagnosed in over 140,000 Americans each year, and takes 51,000 lives. There is need for focused research on this disease in order to identify and implement improved strategies for diagnosing, preventing, and treating it. The Administrative Core facilitates better coordination and savings within core facility use to promote the goals of the Center for Colon Cancer Research at the University of South Carolina.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZGM1-TWD-C)
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University of South Carolina at Columbia
United States
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Oliver, David; Ji, Hao; Liu, Piaomu et al. (2017) Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep 7:43023
Farmaki, Elena; Kaza, Vimala; Papavassiliou, Athanasios G et al. (2017) Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett 389:49-58
Brown, Jacob L; Rosa-Caldwell, Megan E; Lee, David E et al. (2017) Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. J Cachexia Sarcopenia Muscle 8:926-938
Alexander, M; Burch, J B; Steck, S E et al. (2017) Case-control study of candidate gene methylation and adenomatous polyp formation. Int J Colorectal Dis 32:183-192
McDermott, Martina S J; Chumanevich, Alexander A; Lim, Chang-Uk et al. (2017) Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget 8:12558-12575
Zhang, Yu; Davis, Celestia; Shah, Sapana et al. (2017) IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis. Mol Carcinog 56:272-287
Chandrashekaran, Varun; Seth, Ratanesh K; Dattaroy, Diptadip et al. (2017) HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol 13:8-19
Farmaki, E; Chatzistamou, I; Kaza, V et al. (2016) A CCL8 gradient drives breast cancer cell dissemination. Oncogene 35:6309-6318
Narsale, Aditi A; Puppa, Melissa J; Hardee, Justin P et al. (2016) Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice. Oncotarget 7:59482-59502
Peña, Edsel A (2016) Asymptotics for a Class of Dynamic Recurrent Event Models. J Nonparametr Stat 28:716-735

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