The Tissue Biorepository Core has and continues to restructure itself as the most recently added Core Facility of the Center for Colon Cancer Research. It is an IRB-approved biorepository that collects and banks excess surgical specimens. Over the past few years we have initiated and modified protocols for collecting, storing, and distribufing tissue samples and relevant de-identified clinical data to researchers. As such we have been instrumental in the development of a number of research programs that otherwise would not have been feasible without the contributions of the Biorepository. The objective of the Biorepository is to facilitate cancer research, particularly in colon cancer, by providing high quality normal and tumor-derived human tissue along with robust de-identified clinical data to researchers. Our overall long-term goal is to establish this core as a fully functional, efficient and sustainable facility that can confine to efficiently provide high quality de-identified tissue samples and biospecimens to researchers. The CCCR Biorepository is also in an excellent position to contribute important and novel biospecimens to the research community derived from racial/ethnic and underserved populations. Compared to most other states in the US, South Carolina (SC) has a rather large African-American population (31% of the total) living predominantly in rural areas of the state. The demographics of the patient population in SC allow us to develop an inventory of biospecimens that will enable researchers to begin to dissect cancer disparities, one of the major goals of the NCI's 2007 Strategic Plan for Leading the Nation to Eliminate the Suffering and Death Due to Cancer.

Public Health Relevance

The CCCR Biorepository has been operational since 2003 and is an important new Core Facility for the CCCR. The use of human specimens from donor matched sets, combined with information of clinical status and outcome, can provide both genetic and population-based information that will be critical for diagnostics, prognostics and therapeutics as well as the understanding of underlying mechanisms that lead to cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103336-02
Application #
8731925
Study Section
Special Emphasis Panel (ZGM1-TWD-C)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$94,975
Indirect Cost
$29,475
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Liang, Jiaxin; Chen, Mengqian; Hughes, Daniel et al. (2018) CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res 78:6594-6606
Liu, Shou; Lee, Ji Shin; Jie, Chunfa et al. (2018) HER2 Overexpression Triggers an IL1? Proinflammatory Circuit to Drive Tumorigenesis and Promote Chemotherapy Resistance. Cancer Res 78:2040-2051
Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48
Liu, Changlong; Banister, Carolyn E; Weige, Charles C et al. (2018) PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A 115:E5066-E5075
Kaur, Kamaljeet; Saxena, Arpit; Debnath, Irina et al. (2018) Antibiotic-mediated bacteriome depletion in ApcMin/+ mice is associated with reduction in mucus-producing goblet cells and increased colorectal cancer progression. Cancer Med 7:2003-2012
Eberth, Jan M; Thibault, Annie; Caldwell, Renay et al. (2018) A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 124:1912-1920
Farmaki, Elena; Kaza, Vimala; Papavassiliou, Athanasios G et al. (2017) Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett 389:49-58
Brown, Jacob L; Rosa-Caldwell, Megan E; Lee, David E et al. (2017) Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. J Cachexia Sarcopenia Muscle 8:926-938
Hetzler, Kimbell L; Hardee, Justin P; LaVoie, Holly A et al. (2017) Ovarian function's role during cancer cachexia progression in the female mouse. Am J Physiol Endocrinol Metab 312:E447-E459
Chandrashekaran, Varun; Seth, Ratanesh K; Dattaroy, Diptadip et al. (2017) HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. Redox Biol 13:8-19

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