The Tissue Biorepository Core has and continues to restructure itself as the most recently added Core Facility of the Center for Colon Cancer Research. It is an IRB-approved biorepository that collects and banks excess surgical specimens. Over the past few years we have initiated and modified protocols for collecting, storing, and distribufing tissue samples and relevant de-identified clinical data to researchers. As such we have been instrumental in the development of a number of research programs that otherwise would not have been feasible without the contributions of the Biorepository. The objective of the Biorepository is to facilitate cancer research, particularly in colon cancer, by providing high quality normal and tumor-derived human tissue along with robust de-identified clinical data to researchers. Our overall long-term goal is to establish this core as a fully functional, efficient and sustainable facility that can confine to efficiently provide high quality de-identified tissue samples and biospecimens to researchers. The CCCR Biorepository is also in an excellent position to contribute important and novel biospecimens to the research community derived from racial/ethnic and underserved populations. Compared to most other states in the US, South Carolina (SC) has a rather large African-American population (31% of the total) living predominantly in rural areas of the state. The demographics of the patient population in SC allow us to develop an inventory of biospecimens that will enable researchers to begin to dissect cancer disparities, one of the major goals of the NCI's 2007 Strategic Plan for Leading the Nation to Eliminate the Suffering and Death Due to Cancer.

Public Health Relevance

The CCCR Biorepository has been operational since 2003 and is an important new Core Facility for the CCCR. The use of human specimens from donor matched sets, combined with information of clinical status and outcome, can provide both genetic and population-based information that will be critical for diagnostics, prognostics and therapeutics as well as the understanding of underlying mechanisms that lead to cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103336-02
Application #
8731925
Study Section
Special Emphasis Panel (ZGM1-TWD-C)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
$94,975
Indirect Cost
$29,475
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Farmaki, E; Chatzistamou, I; Kaza, V et al. (2016) A CCL8 gradient drives breast cancer cell dissemination. Oncogene 35:6309-6318
Peña, Edsel A; Wu, Wensong; Piegorsch, Walter et al. (2016) Model Selection and Estimation with Quantal-Response Data in Benchmark Risk Assessment. Risk Anal :
Kindo, Bereket P; Wang, Hao; Peña, Edsel A (2016) Multinomial probit Bayesian additive regression trees. Stat (Int Stat Inst) 5:119-131
Wallace, Kristin; Brandt, Heather M; Bearden, James D et al. (2016) Race and Prevalence of Large Bowel Polyps Among the Low-Income and Uninsured in South Carolina. Dig Dis Sci 61:265-72
Watson, Shana R; Liu, Piaomu; Peña, Edsel A et al. (2016) Comparison of Aortic Collagen Fiber Angle Distribution in Mouse Models of Atherosclerosis Using Second-Harmonic Generation (SHG) Microscopy. Microsc Microanal 22:55-62
Jung, Joo-Yong; Gleave Parson, Madeline; Kraft, Jennifer D et al. (2016) Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner. Immunology 149:35-47
Patel, Yogin; Shah, Nirav; Lee, Ji Shin et al. (2016) A novel double-negative feedback loop between miR-489 and the HER2-SHP2-MAPK signaling axis regulates breast cancer cell proliferation and tumor growth. Oncotarget 7:18295-308
Chatzistamou, Ioulia; Kiaris, Hippokratis (2016) Modeling estrogen receptor-positive breast cancers in mice: is it the best we can do? Endocr Relat Cancer 23:C9-C12
Broude, Eugenia V; Győrffy, Balázs; Chumanevich, Alexander A et al. (2015) Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Curr Cancer Drug Targets 15:739-49
Levina, Elina; Ji, Hao; Chen, Mengqiang et al. (2015) Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget 6:13088-104

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