The administrative and mentoring Core is responsible for the overall coordination of activities associated with the COBRE and the Tulane Hypertension and Renal Center of Excellence (THRCE). This involves interactions with departments in the School of Medicine (Medicine, Pediatrics, Physiology, Pharmacology), the School of Public Health and Tropical Medicine (Epidemiology) and the School of Science and Engineering (Biomedical Engineering, Neurosciences). The members of our COBRE in Hypertension and Renal Biology have progressively increased their extramural research support, publications of peer reviewed papers, and presentations at national and international meetings. The efforts have been coordinated by the administrative Core of the COBRE which has been responsible for keeping track of all accomplishments. Under the direction of PI, Dr. L. G. Navar, the program coordinator. Dr. L. Hamm, and the program administrator, Nina R. Majid, the Administrative and Mentoring Core will coordinate and facilitate all the research and training activities supported by the COBRE Cores and Pilot Projects. Accordingly, the Administrative Core will: 1) Provide overall leadership to the COBRE personnel by serving as a resource to the intellectual and mentoring activities of the center. 2) Coordinate and enhance mentoring and research training for career development of COBRE investigators. 3) Provide competent, efficient, and timely oversight of financial activities of the Research Cores and Pilot projects. 4) Enrich the intellectual environment of the Center through regularly scheduled seminars and conferences, support of external consultants, special courses, and various workshops. 5) Encourage multidisciplinary and translational projects by facilitating interactions among investigators from different departments and components of the university. 6) Schedule and organize meetings and activities of the internal steering committee (ISC) and the External Advisory Committee (EAC). 7) Administer all requisite activities of the pilot project grants program. Through the efficient accomplishment and implementation of these varied responsibilities, the administrative and Mentoring Core will provide direction, stability, and leadership to the Phase III program.

Public Health Relevance

Hypertension is a leading cause of death and disability affecting over 50 million people in the United States and responsible for 200,000 deaths annually. The link between hypertension and the kidneys is because many forms of hypertension result from abnormalities in kidney function due either to primary or congenital renal disease or to abnormal hormonal or environmental influences that affect renal function leading to progressive renal and vascular injury.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Tulane University
New Orleans
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Drawz, Paul E; Pajewski, Nicholas M; Bates, Jeffrey T et al. (2017) Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure: Results From the SPRINT (Systolic Blood Pressure Intervention Trial) Ambulatory Blood Pressure Study. Hypertension 69:42-50
Scialla, Julia J; Asplin, John; Dobre, Mirela et al. (2017) Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. Kidney Int 91:204-215
Freedman, Barry I; Rocco, Michael V; Bates, Jeffrey T et al. (2017) APOL1 renal-risk variants do not associate with incident cardiovascular disease or mortality in the Systolic Blood Pressure Intervention Trial. Kidney Int Rep 2:713-720
Singh, Purnima; Castillo, Alexander; Islam, M Toriqul et al. (2017) Evidence for Prohypertensive, Proinflammatory Effect of Interleukin-10 During Chronic High Salt Intake in the Condition of Elevated Angiotensin II Level. Hypertension 70:839-845
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Zhan, Min; St Peter, Wendy L; Doerfler, Rebecca M et al. (2017) Patterns of NSAIDs Use and Their Association with Other Analgesic Use in CKD. Clin J Am Soc Nephrol 12:1778-1786
Berlowitz, Dan R; Foy, Capri G; Kazis, Lewis E et al. (2017) Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes. N Engl J Med 377:733-744
Rodriguez, Carlos J; Still, Carolyn H; Garcia, Katelyn R et al. (2017) Baseline blood pressure control in Hispanics: characteristics of Hispanics in the Systolic Blood Pressure Intervention Trial. J Clin Hypertens (Greenwich) 19:116-125

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