The administrative and mentoring Core is responsible for the overall coordination of activities associated with the COBRE and the Tulane Hypertension and Renal Center of Excellence (THRCE). This involves interactions with departments in the School of Medicine (Medicine, Pediatrics, Physiology, Pharmacology), the School of Public Health and Tropical Medicine (Epidemiology) and the School of Science and Engineering (Biomedical Engineering, Neurosciences). The members of our COBRE in Hypertension and Renal Biology have progressively increased their extramural research support, publications of peer reviewed papers, and presentations at national and international meetings. The efforts have been coordinated by the administrative Core of the COBRE which has been responsible for keeping track of all accomplishments. Under the direction of PI, Dr. L. G. Navar, the program coordinator. Dr. L. Hamm, and the program administrator, Nina R. Majid, the Administrative and Mentoring Core will coordinate and facilitate all the research and training activities supported by the COBRE Cores and Pilot Projects. Accordingly, the Administrative Core will: 1) Provide overall leadership to the COBRE personnel by serving as a resource to the intellectual and mentoring activities of the center. 2) Coordinate and enhance mentoring and research training for career development of COBRE investigators. 3) Provide competent, efficient, and timely oversight of financial activities of the Research Cores and Pilot projects. 4) Enrich the intellectual environment of the Center through regularly scheduled seminars and conferences, support of external consultants, special courses, and various workshops. 5) Encourage multidisciplinary and translational projects by facilitating interactions among investigators from different departments and components of the university. 6) Schedule and organize meetings and activities of the internal steering committee (ISC) and the External Advisory Committee (EAC). 7) Administer all requisite activities of the pilot project grants program. Through the efficient accomplishment and implementation of these varied responsibilities, the administrative and Mentoring Core will provide direction, stability, and leadership to the Phase III program.

Public Health Relevance

Hypertension is a leading cause of death and disability affecting over 50 million people in the United States and responsible for 200,000 deaths annually. The link between hypertension and the kidneys is because many forms of hypertension result from abnormalities in kidney function due either to primary or congenital renal disease or to abnormal hormonal or environmental influences that affect renal function leading to progressive renal and vascular injury.

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National Institute of General Medical Sciences (NIGMS)
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Cedillo-Couvert, Esteban A; Ricardo, Ana C; Chen, Jinsong et al. (2018) Self-reported Medication Adherence and CKD Progression. Kidney Int Rep 3:645-651
Liu, Hongbing; Chen, Shaowei; Yao, Xiao et al. (2018) Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development 145:
Grams, Morgan E; Sang, Yingying; Ballew, Shoshana H et al. (2018) Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int 93:1442-1451
Dobre, Mirela; Gaussoin, Sarah A; Bates, Jeffrey T et al. (2018) Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults. Clin J Am Soc Nephrol 13:596-603
Shapiro, Brian P; Ambrosius, Walter T; Blackshear, Joseph L et al. (2018) Impact of Intensive Versus Standard Blood Pressure Management by Tertiles of Blood Pressure in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension 71:1064-1074
Rocco, Michael V; Sink, Kaycee M; Lovato, Laura C et al. (2018) Effects of Intensive Blood Pressure Treatment on Acute Kidney Injury Events in the Systolic Blood Pressure Intervention Trial (SPRINT). Am J Kidney Dis 71:352-361
Beddhu, Srinivasan; Greene, Tom; Boucher, Robert et al. (2018) Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials. Lancet Diabetes Endocrinol 6:555-563
Anderson, Christopher E; Hamm, L Lee; Batuman, Gem et al. (2018) The association of angiogenic factors and chronic kidney disease. BMC Nephrol 19:117
Lightell Jr, Daniel J; Moss, Stephanie C; Woods, T Cooper (2018) Upregulation of miR-221 and -222 in response to increased extracellular signal-regulated kinases 1/2 activity exacerbates neointimal hyperplasia in diabetes mellitus. Atherosclerosis 269:71-78
Dungan, Kathleen; Craven, Timothy E; Soe, Kyaw et al. (2018) Influence of metabolic syndrome and race on the relationship between intensive blood pressure control and cardiovascular outcomes in the SPRINT cohort. Diabetes Obes Metab 20:629-637

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