The mission of the recently established Inhalation and Pulmonary Physiology Core (IPP Core) facility is to provide the state-of-the-art technology needed by Center for Environmental Health Sciences (CEHS) researchers and others conducting inhalation toxicology and exposure assessment studies. Together with the longer standing Fluorescence Cytometry and Molecular Histology and Fluorescence Imaging Cores (FC and MHFI Cores), the IPP Core provides critical infrastructure to support and enhance the Institution's and Center's research and training goals. The new Core supports the Center's research goal of elucidating the mechanisms leading from exposure to environmental agents to increased morbidity and mortality by providing technology and expertise on inhalation exposures to well characterized test atmospheres of air pollutants, and subsequent evaluation of post-exposure impact on lung function. IPP Core resources include cutting-edge inhalation exposure and pulmonary physiology equipment, a full surgical suite, air sampling equipment, and expertise in the fundamental principles and operation of all Core equipment and services. Exposure facilities include a novel inhalation exposure chamber for studying the effects of inhaled wood smoke, an inhalation chamber for low-level exposures to inhaled methamphetamine, and an ozone exposure chamber. All three chamber systems are flexible and easily adaptable for generating controlled test atmospheres of other gases and particles, alone or in combination. Equipment to perform both invasive and non-invasive murine pulmonary function, human spirometry, air sampling, and nanoparticle characterization together with a full surgical suite complete the resources currently available to the Core. Core personnel provide scientific expertise in inhalation exposure protocol design, sampling and analysis of air pollutants, and training on the use of Core equipment. The combination of available instrumentation and expertise enhances the potential for collaborative efforts within the Center and with other investigators at the University of Montana and across the region, and thus contributes to CEHS'sustainability.

Public Health Relevance

The Inhalation and Pulmonary Physiology Core provides state-of-the-science technical and expert support to CEHS and other investigators on the development and implementation of experimental protocols for performing controlled exposures to gas- and particle-phase airborne agents, and measurement of murine lung function. These resources are critical to the scientific competiveness and sustainability of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM103338-01A1
Application #
8542080
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-03-31
Support Year
1
Fiscal Year
2013
Total Cost
$116,588
Indirect Cost
$34,194
Name
University of Montana
Department
Type
DUNS #
010379790
City
Missoula
State
MT
Country
United States
Zip Code
59812
Larson, Erica L; Vanderpool, Dan; Keeble, Sara et al. (2016) Contrasting Levels of Molecular Evolution on the Mouse X Chromosome. Genetics 203:1841-57
Brown, Traci A; Lee, Joong Won; Holian, Andrij et al. (2016) Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure. Nanotoxicology 10:453-61
Ferguson, Matthew D; Semmens, Erin O; Dumke, Charles et al. (2016) Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations. J Occup Environ Med 58:407-13
Jessop, Forrest; Hamilton, Raymond F; Rhoderick, Joseph F et al. (2016) Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure. Toxicol Appl Pharmacol 309:101-10
Brown, Traci Ann; Holian, Andrij; Pinkerton, Kent E et al. (2016) Early life exposure to environmental tobacco smoke alters immune response to asbestos via a shift in inflammatory phenotype resulting in increased disease development. Inhal Toxicol 28:349-56
Lee, Joong Won; Jaffar, Zeina; Pinkerton, Kent E et al. (2015) Alterations in DNA methylation and airway hyperreactivity in response to in utero exposure to environmental tobacco smoke. Inhal Toxicol 27:724-30
Montrose, Luke; Noonan, Curtis W; Cho, Yoon Hee et al. (2015) Evaluating the effect of ambient particulate pollution on DNA methylation in Alaskan sled dogs: potential applications for a sentinel model of human health. Sci Total Environ 512-513:489-94
Jessop, Forrest; Holian, Andrij (2015) Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammation in vivo. Nanotoxicology 9:365-72
Lacher, Sarah E; Skagen, Kasse; Veit, Joachim et al. (2015) P-Glycoprotein Transport of Neurotoxic Pesticides. J Pharmacol Exp Ther 355:99-107
Cho, Yoon Hee; Woo, Hae Dong; Jang, Yoonhee et al. (2015) The Association of LINE-1 Hypomethylation with Age and Centromere Positive Micronuclei in Human Lymphocytes. PLoS One 10:e0133909

Showing the most recent 10 out of 21 publications