Our ten-year COBRE, """"""""Mentoring Neuroscience in Louisiana"""""""" (P20RR016816, 2002-2012) has been a transformative force that provided growth of neuroscience research in our region. It also allowed to sustain research in spite of Hurricanes Katrina and Rita. The COBRE provided mentoring and support to launch eight independent research careers. The infrastructure created led to the recruitment of 10 independent scientists. This P30 COBRE Phase III award is focused on critical infrastructure that includes (a) Core support for 19 neuroscience laboratories at LSUHSC, Tulane, Xavier and Nicholls State University;and (b) pilot projects to enable investigators to achieve R01 and similar grant support. Mentoring and Core support are the central themes during the transitional period to attain sustainability of the Cores and further success. The Multiphoton Confocal Microscopy Core allows for characterization of dendritic integration in the hippocampus. In particular, the dual scanner set-up was used to define differently distributed syaptic input, the form of dendritic integration, and action potential output in the apical dendrites of hippocampal CA1 neurons. The Mediator Lipidomics Core was essential in the discovery of neuroprotectin D1 and in beginning to define inflammatory resolution circuits in the brain and other tissues. The Computational Neuroscience Core expands on strengths in simulation and modeling. The Imaging Core assists investigators with state-of-the- art technologies for tissue analysis and cellular and molecular imaging. The Pilot Project Program will identify, support and mentor scientists through one-year pilot projects. These pilot funds are fundamental to our plans for the future sustainability. The Administrative Core will provide mentoring teams and administrative support, implement and expand multidisciplinary enrichment programs, support collaborations, and evaluate and manage the effectiveness of pilot projects. We are confident that with these resources we will make a smooth transition to a sustained, outstanding, trans-institutional Center of Neuroscience Excellence.

Public Health Relevance

This COBRE has led to a remarkable expansion in neuroscience research in the New Orleans region. Through recruiting and development of scientists, this funding mechanism has resulted in exciting discoveries in experimental stroke, active dendritic processing, and Alzheimer's disease. Transition to a P30 Center with four essential neuroscience Core Facilities will help launch additional new careers and facilitate sustained program support from federal agencies.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Zlotnik, Hinda
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State Univ Hsc New Orleans
Schools of Medicine
New Orleans
United States
Zip Code
Pham, Thang Luong; He, Jiucheng; Kakazu, Azucena H et al. (2017) Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration. J Biol Chem 292:18486-18499
Lin, Eric C; Combe, Crescent L; Gasparini, Sonia (2017) Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex. Front Cell Neurosci 11:182
He, Jiucheng; Pham, Thang Luong; Kakazu, Azucena et al. (2017) Recovery of Corneal Sensitivity and Increase in Nerve Density and Wound Healing in Diabetic Mice After PEDF Plus DHA Treatment. Diabetes 66:2511-2520
Belayev, Ludmila; Mukherjee, Pranab K; Balaszczuk, Veronica et al. (2017) Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke. Cell Death Differ 24:1091-1099
Alapure, Bhagwat V; Lu, Yan; Peng, Hongying et al. (2017) Surgical Denervation of Specific Cutaneous Nerves Impedes Excisional Wound Healing of Small Animal Ear Pinnae. Mol Neurobiol :
Jun, Bokkyoo; Mukherjee, Pranab K; Asatryan, Aram et al. (2017) Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity. Sci Rep 7:5279
Bhattacharjee, Surjyadipta; Jun, Bokkyoo; Belayev, Ludmila et al. (2017) Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury. Sci Adv 3:e1700735
He, Jiucheng; Cosby, Richard; Hill, James M et al. (2017) Changes in Corneal Innervation after HSV-1 Latency Established with Different Reactivation Phenotypes. Curr Eye Res 42:181-186
Asatryan, Aram; Bazan, Nicolas G (2017) Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. J Biol Chem 292:12390-12397
Canavier, Carmen C; Tikidji-Hamburyan, Ruben A (2017) Globally attracting synchrony in a network of oscillators with all-to-all inhibitory pulse coupling. Phys Rev E 95:032215

Showing the most recent 10 out of 73 publications