We are submitting this renewal application for the Cardiovascular Center of Biomedical Research Excellence (COBRE) at the University of Hawaii (UH) in response to the National Institutes of Health PAR-10-196. The John A. Burns School of Medicine has established a Center for Cardiovascular Research (OCR), led by Dr. Ralph Shohet, an R01-funded molecular cardiologist. During the NCRR's investment in our Center through two previous cycles of funding, our junior investigators have successfully competed for 6 new R01s and 3 R21s, in addition to NSF, AHA, and local philanthropic funding. During the past five years we recruited two senior faculty and 3 junior faculty to our program using a combination of institutional and COBRE support. We have also established three Core laboratories that provide crucial services for modern biomedical science, in Genomics, Histopathology, and Mouse Physiology. These accomplishments fulfill the initial goals of the Cardiovascular COBRE program to strengthen the biomedical research capacity of the Medical School and the University and enhance the ability of our investigators to compete for independent extramural funding. We plan to build upon the success of the first two COBRE cycles by enhancing these core facilities and placing them on a secure and sustainable financial basis, so that they can continue to support biomedical research at our institution. Our long-term goal is to continue to train and support the cadre of skilled researchers whose studies will ultimately reduce heart disease and eliminate cardiovascular health disparities among the diverse ethnic groups of Hawaii, particularly Native Hawaiians. Our two specific aims are: 1. to maintain the growth and enhance the sustainability of Core services, and 2. to develop a pilot project program that will fund the best ideas of our investigators to the point where they are competitive for extramural support.

Public Health Relevance

(provided by applicant): With a new campus, new faculty, and renascent administration, our Medical School has embarked on a new direction, developing into a research-centric school that will address the medical problems of our population at a basic level, and provide a new bioscience component to our economy. These Cores provide the capabilities required for modern biomedical science and in some cases are the only such resources in the State.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM103341-01
Application #
8305804
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Gorospe, Rafael
Project Start
2012-09-24
Project End
2017-07-31
Budget Start
2012-09-24
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$916,349
Indirect Cost
$443,164
Name
University of Hawaii
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Meiler, Svenja; Baumer, Yvonne; McCurdy, Sara et al. (2015) Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report. Arterioscler Thromb Vasc Biol 35:309-11
Meiler, Svenja; Baumer, Yvonne; Toulmin, Emma et al. (2015) MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis. Arterioscler Thromb Vasc Biol 35:323-31
Koenig, Matthew A; Holt, John L; Ernst, Thomas et al. (2014) MRI default mode network connectivity is associated with functional outcome after cardiopulmonary arrest. Neurocrit Care 20:348-57
Koenig, Matthew A (2014) Brain resuscitation and prognosis after cardiac arrest. Crit Care Clin 30:765-83
Gu, Se Hun; Hejduk, Janusz; Markowski, Janusz et al. (2014) Co-circulation of soricid- and talpid-borne hantaviruses in Poland. Infect Genet Evol 28:296-303
Boulay, Rachel; van Raalte, Lisa (2014) Impacting the Science Community through Teacher Development: Utilizing Virtual Learning. Int J Technol Knowl Soc 9:13-24
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh et al. (2014) The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol 184:159-70
Fong, Keith S K; Adachi, Dana A T; Chang, Shaun B et al. (2014) Midline craniofacial malformations with a lipomatous cephalocele are associated with insufficient closure of the neural tube in the tuft mouse. Birth Defects Res A Clin Mol Teratol 100:598-607
Simsekyilmaz, Sakine; Cabrera-Fuentes, Hector A; Meiler, Svenja et al. (2014) Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 129:598-606
Yamauchi, Yasuhiro; Riel, Jonathan M; Stoytcheva, Zoia et al. (2014) Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science 343:69-72

Showing the most recent 10 out of 15 publications