Our Histopathology Core is a joint effort of the Center for Cardiovascular Research and the Department of Cell &Molecular Biology and has been supported by both the Cardiovascular COBRE and the Research Centers in Minority Institutions programs at the Medical School. We plan to continue this very productive collaborative effort, between two NCRR-funded programs, in the third cycle of COBRE funding in order to provide modern histology and microscopy services to the growing number of basic science investigators at the John A. Burns School of Medicine.
Our aims will support these goals:
Aim 1. Continue to provide histology and microscopy services at favorable cost to investigators at the medical school, with increased provision of these services to the broader University and other investigators throughout Hawaii. The Core provides access to histology and microscopy that produce both less expensive and higher quality histological evaluation for our investigators than they could otherwise obtain. The data provided is crucial for competitive grant applications.
Aim 2. Continue and enhance instructional efforts to increase understanding and efficient use of the histology core. Cores provide a crucial service not only in generating high quality data, but also teaching our investigators how to use this capability in their work.
Aim 3. Foster innovation in the Core through judicious additions of new expertise and technologies. We will increase the level of technical and supervisory consultation available in the Core by bringing both an experienced ASCP certified histopathology technician and a Ph.D. trained Pathologist into the Core. We will also add at least two cutting-edge technologies to the core offerings through collaboration with other laboratories at UH: atomic force microscopy and mass spectrometry of histological samples will be added to our repertoire.

Public Health Relevance

We plan to offer highly valued histology services to an increasing number of investigators, education in the use of Core methods to an increasing number of students and staff, and the introduction of previously unavailable expertise for histology and exciting new technologies to enhance the research effort at our school. We anticipate achieving sustainability through a combination of increasing receipts from a growing research enterprise and from institutional support in recognition of the crucial value of our services.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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University of Hawaii
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Meiler, Svenja; Baumer, Yvonne; McCurdy, Sara et al. (2015) Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report. Arterioscler Thromb Vasc Biol 35:309-11
Meiler, Svenja; Baumer, Yvonne; Toulmin, Emma et al. (2015) MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis. Arterioscler Thromb Vasc Biol 35:323-31
Koenig, Matthew A; Holt, John L; Ernst, Thomas et al. (2014) MRI default mode network connectivity is associated with functional outcome after cardiopulmonary arrest. Neurocrit Care 20:348-57
Koenig, Matthew A (2014) Brain resuscitation and prognosis after cardiac arrest. Crit Care Clin 30:765-83
Gu, Se Hun; Hejduk, Janusz; Markowski, Janusz et al. (2014) Co-circulation of soricid- and talpid-borne hantaviruses in Poland. Infect Genet Evol 28:296-303
Boulay, Rachel; van Raalte, Lisa (2014) Impacting the Science Community through Teacher Development: Utilizing Virtual Learning. Int J Technol Knowl Soc 9:13-24
Brampton, Christopher; Aherrahrou, Zouhair; Chen, Li-Hsieh et al. (2014) The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol 184:159-70
Fong, Keith S K; Adachi, Dana A T; Chang, Shaun B et al. (2014) Midline craniofacial malformations with a lipomatous cephalocele are associated with insufficient closure of the neural tube in the tuft mouse. Birth Defects Res A Clin Mol Teratol 100:598-607
Simsekyilmaz, Sakine; Cabrera-Fuentes, Hector A; Meiler, Svenja et al. (2014) Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 129:598-606
Yamauchi, Yasuhiro; Riel, Jonathan M; Stoytcheva, Zoia et al. (2014) Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science 343:69-72

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