The Morphology, Imaging and Instrumentation Core (B) provides the space, facilities, supervision, and training for investigators who use histological methods, and advanced imaging technology to answer research questions. This core builds on research investments from NIH/NCRR Shared Instrumentation Grants, NIH/NCRR COBRE Phase I and II programs, and an NSF Research Infrastructure Improvement Award. Core B provides skilled personnel capable of performing and training users in highly specialized techniques, such as confocal imaging, 3D reconstruction, immunohistochemistry, in situ hybridization, cell sorting, ultrasound, and image analysis;and offers advice with experimental design and analysis of data.
Specific aims are: (a) to maintain the resources for safe and effective use by properly trained research personnel;(b) to assist research projects perform high quality and state-of-the-art image acquisition and data analyses;(c) to help in the design and performance of immunohistochemical and in situ hybridization analyses;(d) to provide a state-of-the-art cell sorting service, and (e) provide programs of outreach and education to investigators using methods and instrumentation available in the core. Faculty and student investigators have access to core facilities to process tissue and operate the histological tools, microscopes, and analysis computers, and are assisted by core staff concerning experimental design, data interpretation and technical information to best utilize facilities and instrumentation. The Core has a 15-year record of providing state-of-the-art service and training to investigators at MUSC and throughout South Carolina. Core staff participates in a weeklong training workshop on confocal microscopy (since 2004), acts as a Beckman Coulter Center of Excellence for development of flow cytometry, and has strong interactions with imaging cores in COBREs at Clemson (Biomaterials) and the University of South Carolina (Colon Cancer).
Cardiovascular diseases are the primary cause of morbidity and mortality in the U.S. This Center of Biomedical Research Excellence conducts research in the mechanisms of normal and abnormal heart development, the developmental basis of adult cardiovascular diseases, and the application of the principles of normal development to guide stem-cell based, tissue regeneration or replacement. The Morphology, Imaging and Instrumentation Core provides advanced imaging and histology support to this effort.
|Daoud, Abdelkader; Gopal, Udhayakumar; Kaur, Jasmine et al. (2017) Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling. Oncotarget 8:106807-106819|
|Beiko, Tatsiana; Janech, Michael G; Alekseyenko, Alexander V et al. (2017) Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis 4:204-216|
|Ghatak, Shibnath; Markwald, Roger R; Hascall, Vincent C et al. (2017) Transforming growth factor ?1 (TGF?1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. J Biol Chem 292:10465-10489|
|Pulkoski-Gross, Michael J; Uys, Joachim D; Orr-Gandy, K Alexa et al. (2017) Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat 130:47-56|
|Tan, Yu; Richards, Dylan; Coyle, Robert C et al. (2017) Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. Acta Biomater 51:495-504|
|Chen, Wei; Zhang, Yong-Mei; Davies, Christopher (2017) Penicillin-Binding Protein 3 Is Essential for Growth of Pseudomonas aeruginosa. Antimicrob Agents Chemother 61:|
|Richards, Dylan; Jia, Jia; Yost, Michael et al. (2017) 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng 45:132-147|
|Ghatak, Shibnath; Hascall, Vincent C; Markwald, Roger R et al. (2017) Transforming growth factor ?1 (TGF?1)-induced CD44V6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis. J Biol Chem 292:10490-10519|
|Richards, Dylan J; Coyle, Robert C; Tan, Yu et al. (2017) Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials 142:112-123|
|Nolan, Krystal D; Kaur, Jasmine; Isaacs, Jennifer S (2017) Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity. Oncotarget 8:19323-19341|
Showing the most recent 10 out of 61 publications