This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE """"""""Cardiovascular Developmental Biology Center"""""""" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development;investigating the developmental basis of adult cardiovascular diseases;and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three """"""""cradle to grave"""""""" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.

Public Health Relevance

Cardiovascular diseases (pediatric and adult) are the primary cause of morbidity and mortality in the U.S. This Center of Biomedical Research Excellence conducts research and training in the mechanisms of normal and abnormal heart development, the developmental basis of adult cardiovascular diseases, and the application of the principles of normal development to guide stem-cell based, tissue regeneration or replacement.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103342-03
Application #
8657064
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Taylor, Fred
Project Start
2012-08-01
Project End
2017-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Charleston
State
SC
Country
United States
Zip Code
29403
Richards, Dylan J; Tan, Yu; Coyle, Robert et al. (2016) Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids. Nano Lett 16:4670-8
Fresco, Victor M; Kern, Christine B; Mohammadi, Moosa et al. (2016) Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL. J Biol Chem 291:18730-9
Dupuis, Loren E; Doucette, Lorna; Rice, A Kittrell et al. (2016) Development of myotendinous-like junctions that anchor cardiac valves requires fibromodulin and lumican. Dev Dyn 245:1029-42
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Mallanna, Sunil K; Cayo, Max A; Twaroski, Kirk et al. (2016) Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. Stem Cell Reports 7:543-56
Briggs, Laura E; Burns, Tara A; Lockhart, Marie M et al. (2016) Wnt/β-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion. Dev Dyn 245:103-13
Arif, Ehtesham; Sharma, Pankaj; Solanki, Ashish et al. (2016) Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1. Mol Cell Biol 36:1639-54
Grek, Christina L; Rhett, J Matthew; Bruce, Jaclynn S et al. (2016) Connexin 43, breast cancer tumor suppressor: Missed connections? Cancer Lett 374:117-26
Jia, Jia; Coyle, Robert C; Richards, Dylan J et al. (2016) Development of peptide-functionalized synthetic hydrogel microarrays for stem cell and tissue engineering applications. Acta Biomater 45:110-120
Richards, Dylan; Jia, Jia; Yost, Michael et al. (2016) 3D Bioprinting for Vascularized Tissue Fabrication. Ann Biomed Eng :

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