The overall goal of this proposal is to transition our existing Phase Ii COBRE research program and core facilities into a nationally recognized research center that can compete for COBRE-independent NIH center grants. During COBRE Phase I, we succeeded in developing an integrated program in CNS pathophysiology research, and built a 11,000 ft[2] dedicated comprehensive neuroimaging facility called Biomedical Research and Integrative Neuroimaging (BRaIN Imaging) Center with a C06 grant from the NCRR. During Phase II, we have upgraded our state-of-the-art multimodal neuroimaging core facilities and used the facilities as the infrastructure for successfully mentoring our junior PIs. During Phase I and II, 6 out of 9 junior PIs in the COBRE successfully obtained a total of 9 new NIH R01 grants. Our peer-reviewed publications and number of grants also increased significantly. In support of this application we have obtained institutional support of ~$500,000 to upgrade our MR scanner into a phase array system and additional ~$400,000 to support the administration of the Phase III program. The funds requested in this application will be used support the Core facilities (personnel and operating costs of three cores - Magnetic Resonance Imaging (MRI), Electron Paramagnetic Resonance Imaging (EPRI) and Optical / Electrophysiology core that has a 2-photon laser scanning microscope) and a Pilot Project Program (PPP). The support of the core facilities and PPP is crucial for bringing our research program to a level competitive at the national level. During the last 8 years, our research program has evolved into four distinct topics: i) Molecular mechanism of BBB disruption;ii) Cerebral oxygenation and its potential as a viable clinical therapy;iii) Stem cells and neuroregeneration;and iv) Molecular mechanisms of neuronal injury. Our research strategy is to build a coherent, synergistic research program under the umbrella of CNS pathophysiology led by the PI of this application who will work with the group leaders of these four topics.
The specific aims of the proposed Phase III COBRE are to: (1) maintain and expand the comprehensive neuroimaging core facilities that will support the conduct of basic and translational research in the area of CNS pathophysiology at UNM;and (2) sustain and expand a collaborative and multidisciplinary research environment by enhancing the focus on neuroimaging research and increasing the number of NIH-funded investigators through the proposed overall strategic planning and PPP.

Public Health Relevance

The proposed Phase III COBRE program will significantly increase our research capabilities in the preclinical translational research in biomedical sciences at our institution in New Mexico, in concert with our institutional effort to create the Clinical Translational Science Center (CTSC), and will contribute to the improvement of health care in New Mexico and in this country.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103400-04
Application #
8628139
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Program Officer
Liu, Yanping
Project Start
2011-03-15
Project End
2016-02-29
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
4
Fiscal Year
2014
Total Cost
$1,061,222
Indirect Cost
$351,902
Name
University of New Mexico Health Sciences Center
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Meyer, Matthias R; Fredette, Natalie C; Daniel, Christoph et al. (2016) Obligatory role for GPER in cardiovascular aging and disease. Sci Signal 9:ra105
Rodriguez, Carlos I; Davies, Suzy; Calhoun, Vince et al. (2016) Moderate Prenatal Alcohol Exposure Alters Functional Connectivity in the Adult Rat Brain. Alcohol Clin Exp Res 40:2134-2146
Bragin, D E; Peng, Z; Bragina, O A et al. (2016) Improvement of Impaired Cerebral Microcirculation Using Rheological Modulation by Drag-Reducing Polymers. Adv Exp Med Biol 923:239-44
Welch, J H; Mayfield, J J; Leibowitz, A L et al. (2016) Third trimester-equivalent ethanol exposure causes micro-hemorrhages in the rat brain. Neuroscience 324:107-18
Robinson, Shenandoah; Berglass, Jacqueline B; Denson, Jesse L et al. (2016) Microstructural and microglial changes after repetitive mild traumatic brain injury in mice. J Neurosci Res :
Dai, Xingping; Bragina, Olga; Zhang, Tongsheng et al. (2016) High Intracranial Pressure Induced Injury in the Healthy Rat Brain. Crit Care Med 44:e633-8
Fricke, G Matthew; Letendre, Kenneth A; Moses, Melanie E et al. (2016) Persistence and Adaptation in Immunity: T Cells Balance the Extent and Thoroughness of Search. PLoS Comput Biol 12:e1004818
Zheng, Handong; Zhang, Xing; Castillo, Eliseo F et al. (2016) Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease. J Biol Chem 291:22043-22052
Ding, Xiaofeng; Luo, Yan; Zhang, Xing et al. (2016) IL-33-driven ILC2/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity. J Endocrinol 231:35-48
Bragin, Denis E; Thomson, Susan; Bragina, Olga et al. (2016) Drag-Reducing Polymer Enhances Microvascular Perfusion in the Traumatized Brain with Intracranial Hypertension. Acta Neurochir Suppl 122:25-9

Showing the most recent 10 out of 60 publications