Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and """"""""Lung Biology"""""""" COBREs at Dartmouth and the Univesrity of Vermont;and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

Public Health Relevance

The immune system is central to a variety of disease states, from protective responses to microbial infections and tumors, to unwanted inflammation and immunopathology characteristic of allergy, autoimmunity, etc. A better understanding of how to regulate the immune system is needed to create better vaccines, or to limit immune responses in syndromes resulting from an overzealous recognition of non-dangerous antigen.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Gorospe, Rafael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Schools of Medicine
United States
Zip Code
Shen, Zheng; Rodriguez-Garcia, Marta; Ochsenbauer, Christina et al. (2017) Characterization of immune cells and infection by HIV in human ovarian tissues. Am J Reprod Immunol 78:
Shen, Zheng; Rodriguez-Garcia, Marta; Patel, Mickey V et al. (2017) Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+?T cells. Sci Rep 7:17697
Howe, Caitlin G; Li, Zhigang; Zens, Michael S et al. (2017) Dietary B Vitamin Intake Is Associated with Lower Urinary Monomethyl Arsenic and Oxidative Stress Marker 15-F2t-Isoprostane among New Hampshire Adults. J Nutr 147:2289-2296
Rodriguez-Garcia, Marta; Patel, Mickey V; Shen, Zheng et al. (2017) Tenofovir Inhibits Wound Healing of Epithelial Cells and Fibroblasts from the Upper and Lower Human Female Reproductive Tract. Sci Rep 8:45725
Malik, Brian T; Byrne, Katelyn T; Vella, Jennifer L et al. (2017) Resident memory T cells in the skin mediate durable immunity to melanoma. Sci Immunol 2:
Butler, Kiah L; Clancy-Thompson, Eleanor; Mullins, David W (2017) CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases. Sci Rep 7:45593
Mustachio, Lisa Maria; Lu, Yun; Tafe, Laura J et al. (2017) Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer. Mol Cancer Res 15:905-914
Steinberg, Shannon M; Shabaneh, Tamer B; Zhang, Peisheng et al. (2017) Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors. Cancer Res 77:1599-1610
Obar, Joshua J; Hohl, Tobias M; Cramer, Robert A (2016) New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches. Cytokine 84:63-73
Rastad, Jessica L; Green, William R (2016) Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-?. Virology 499:9-22

Showing the most recent 10 out of 39 publications