The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neuroscience at the University of Vermont (UVM), established in 2001, has been to integrate and expand neuroscience research and training at UVM by building a collaborative intellectual infrastructure, developing cutting-edge shared core facilities, supporting recruitment of new junior faculty, and by providing research project and pilot project funding for neuroscience faculty in multiple colleges. The Neuroscience COBRE expanded interdisciplinary neuroscience research and promoted translational research by increasing the interaction between basic and clinical neuroscientists. COBRE funding has been instrumental in developing an excellent research infrastructure that has allowed the neuroscience community to compete successfully for new institutional funds and extramural support. As the neuroscience faculty enterprise has grown, neuroscience has been designated an area of research and training emphasis at UVM. The primary objective of the next grant cycle is to build upon our success and continue to support the infrastructure of neuroscience research and training at UVM. The goals are: Goal 1: To support the intellectual environment and research opportunities of neuroscientists at UVM by (1) maintaining a vigorous mentoring program to promote success of pilot project grant directors and newly recruited junior neuroscience investigators, (2) supporting a University-wide Neuroscience Seminar Series and Annual Retreat, (3) supporting Pilot Project grants, (4) facilitating the growth and productivity of the university-wide Neuroscience Graduate Program and (5) facilitating dialogue between basic and clinical scientists that promotes development of collaborative and translational research. Goal 2: To support the infrastructure for neuroscience research and training at UVM by fostering the continued growth of two Neuroscience COBRE multi-user research cores: an Imaging/Physiology Core and Cell/Molecular Biology Core. In particular, the Neuroscience COBRE grant will ensure continued growth in sophistication of equipment and research training offered through the Imaging/Physiology Core and Cell/Molecular Biology Core.

Public Health Relevance

The primary goal of the Neuroscience COBRE is to support the infrastructure of neuroscience research and training at the University of Vermont (UVM). This support will allow investigators to ask clinically relevant questions and answer them using state-of-the-art facilities. UVM is the only doctoral degree granting institution in a state with limited resources due to its tax base of fewer than 625,000 people. Continued support of the Neuroscience COBRE by the National Center for Research Resources over the next funding cycle will ensure a return on investment that will benefit the University, the State of Vermont and the national research enterprise.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM103498-04
Application #
8733180
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Canto, Maria Teresa
Project Start
2011-08-01
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
$1,065,906
Indirect Cost
$366,951
Name
University of Vermont & St Agric College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Harraz, Osama F; Longden, Thomas A; Hill-Eubanks, David et al. (2018) PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife 7:
Sheehe, Jessica L; Bonev, Adrian D; Schmoker, Anna M et al. (2018) Oxidation of cysteine 117 stimulates constitutive activation of the type I? cGMP-dependent protein kinase. J Biol Chem 293:16791-16802
Parsons, Rodney L; May, Victor (2018) PACAP-Induced PAC1 Receptor Internalization and Recruitment of Endosomal Signaling Regulate Cardiac Neuron Excitability. J Mol Neurosci :
Heppner, David E; Dustin, Christopher M; Liao, Chenyi et al. (2018) Direct cysteine sulfenylation drives activation of the Src kinase. Nat Commun 9:4522
Harraz, Osama F; Longden, Thomas A; Dabertrand, Fabrice et al. (2018) Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion. Proc Natl Acad Sci U S A 115:E3569-E3577
Tacoma, R; Fields, J; Ebenstein, D B et al. (2017) Ratio of dietary rumen degradable protein to rumen undegradable protein affects nitrogen partitioning but does not affect the bovine milk proteome produced by mid-lactation Holstein dairy cows. J Dairy Sci 100:7246-7261
Balbi, Matilde; Koide, Masayo; Schwarzmaier, Susanne M et al. (2017) Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. J Cereb Blood Flow Metab 37:178-187
Farina, Nicholas H; Ramsey, Jon E; Cuke, Melissa E et al. (2017) Development of a predictive miRNA signature for breast cancer risk among high-risk women. Oncotarget 8:112170-112183
Syed, Arsalan U; Koide, Masayo; Brayden, Joseph E et al. (2017) Tonic regulation of middle meningeal artery diameter by ATP-sensitive potassium channels. J Cereb Blood Flow Metab :271678X17749392
Jacobs, Jesse V; Lyman, Courtney A; Hitt, Juvena R et al. (2017) Task-related and person-related variables influence the effect of low back pain on anticipatory postural adjustments. Hum Mov Sci 54:210-219

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