Established during 2000, the Nebraska Center for Virology (NCV;P20RR015635) is a multi-institutional, interdisciplinary center linking the virology expertise and resources at Nebraska's major biomedical research institutions: the University of Nebraska-Lincoln, the University of Nebraska Medical Center, and Creighton University. NCV investigators study human, animal, and plant viruses;their collective expertise presents a national strength and an exceptional opportunity to collaborate on model systems expected to lead to new approaches to understand and treat diseases threatening human health and economic well-being. Following nine years of COBRE program support, the NCV is developing a global research and training presence, and establishing an interdisciplinary research program addressing fundamental questions about infectious agents and their host interactions and creating an environment that is producing a new generation of innovative researchers with a broad knowledge of virology. COBRE support has allowed the Center to establish a critical mass of focused virology expertise and resources on each participating campus;however, to become an independent center, the NCV must bolster its interdisciplinary and cross-campus collaborations and implement a sustainability plan for its core facilities. In addition, several promising junior faculty conducting highly meritorious research continue to need NCV support and mentoring to gain independence. Additional capacity built through Phase III COBRE funding will enable the NCV to realize its strategic plan and achieve its long-term vision: to become an internationally recognized center of research excellence, with outstanding core facilities that serve IDeA, regional, and international scientific communities. This vision will be realized by completing three specific aims: 1) increase the research productivity and external funding potential of NCV faculty by continuing an effective mentoring program for junior faculty, sponsoring a pilot project program, and continuing support for four essential core facilities (administrative, flow cytometry, microscopy, and proteomics);2) strengthen the NCV's focus on translational research and virology research training and education through new partnerships and programs to share viral immunology and molecular virology expertise and scientific resources with researchers, clinicians, and students globally;and 3) emerge from COBRE Phase III funding as a self-sustaining center of research excellence in virology by diversifying the NCV's external research funding portfolio through increased individual-investigator and collaborative grant productivity.

Public Health Relevance

Phase III COBRE funding will ideally position the Nebraska Center for Virology to provide the infrastructure support needed to increase understanding of the molecular mechanisms by which different viral agents establish persistent infection, interact with the host, are transmitted from one host to another, and cause disease - with the ultimate goal of contributing to new strategies to treat and prevent such infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
8P30GM103509-03
Application #
8309873
Study Section
Special Emphasis Panel (ZRR1-RI-2 (01))
Program Officer
Liu, Yanping
Project Start
2010-09-16
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$1,104,470
Indirect Cost
$357,243
Name
University of Nebraska Lincoln
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68588
Tyler, Kimberly A; Handema, Ray; Schmitz, Rachel M et al. (2016) Risk Factors for HIV among Zambian Street Youth. J HIV AIDS Soc Serv 15:254-268
Wiebe, Matthew S; Jamin, Augusta (2016) The Barrier to Autointegration Factor: Interlocking Antiviral Defense with Genome Maintenance. J Virol 90:3806-9
Diamond, Judy; McQuillan, Julia; Spiegel, Amy N et al. (2016) Viruses, Vaccines and the Public. Mus Soc Issues 11:9-16
Tyler, Kimberly A; Handema, Ray; Schmitz, Rachel M et al. (2016) Multi-Level Risk and Protective Factors for Substance Use Among Zambian Street Youth. Subst Use Misuse 51:922-31
Anandhan, Annadurai; Lei, Shulei; Levytskyy, Roman et al. (2016) Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions. Mol Neurobiol :
Ye, Fengchun; Zeng, Yan; Sha, Jingfeng et al. (2016) High Glucose Induces Reactivation of Latent Kaposi's Sarcoma-Associated Herpesvirus. J Virol :
Yuan, Zhe; Kang, Guobin; Ma, Fangrui et al. (2016) Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice. J Virol 90:7728-39
Sun, Ming; Li, Yue; Yuan, Zhe et al. (2016) VRC01 antibody protects against vaginal and rectal transmission of human immunodeficiency virus 1 in hu-BLT mice. Arch Virol 161:2449-55
Kelly, Abby M; Plautz, Sarah A; Zempleni, Janos et al. (2016) Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem Cells. Mol Ther 24:331-41
Navarro-Yepes, Juliana; Anandhan, Annadurai; Bradley, Erin et al. (2016) Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways. Mol Neurobiol 53:5229-51

Showing the most recent 10 out of 127 publications