The Administrative Core provides the umbrella for effective operation of nearly all components ofthe COBRE program. An objective ofthe Administrative Core is to provide an efficient and effective organizational structure in which to ensure excellence in management, integration and oversight ofthe COBRE across Departments and the LSUHSC. The COBRE Director and Program Coordinator are supported in their administrative responsibilities by an Internal Steering Committee and an External Advisory Committee, which provide routine oversight and guidance regarding the programs research. Core, mentoring, and administrative components. The Internal Steering Committee will oversee program management and development ofthe Cardiovascular Center. Accordingly, the Administrative core will: 1) provide strong leadership to COBRE and Cardiovascular Center investigators over the next 5 years;2) provide support to sustain and enhance the services and state-of-art equipment available to investigators through our Core Facilities;3) sustain an enriched mentoring environment in which to provide vision and guidance to each cardiovascular investigator in relation to scientific and career development;4) provide an effective mechanism for recruitment of new cardiovascular investigators into the Cardiovascular Center;5) provide effective fiscal and administrative management ofall components ofthe COBRE program and Cardiovascular Center including oversight and management of COBRE pilot project awards;6) review the scientific accomplishments of our Cardiovascular Center investigators and the status ofthe overall research program with members ofthe Internal Steering Committee and the External Advisory Committee, and to construct effective means to resolve weaknesses;7) enhance scientific interactions and potential research collaborations through an active cardiovascular seminar series and organization of mini-symposia;8) provide continued career development through research training offered by our COBRE/University Core Facilities, LSUHSC Office of Research Services, and sponsorship of workshops;and 9) enhance translational research by fostering research collaborations and discussions between basic science and clinical-scientist.

Public Health Relevance

The Administrative Core provides the structural foundation of the program and hub for coordinated administrative management, integration, and oversight ofthe proposed COBRE program and it's fiscal, mentoring, core facilities, and scientific pilot project components.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZGM1-TWD-C (C3))
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Louisiana State Univ Hsc New Orleans
New Orleans
United States
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Trivedi, Rishi K; Polhemus, David J; Li, Zhen et al. (2018) Combined Angiotensin Receptor-Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure. J Am Heart Assoc 7:
Tsumagari, Koji; Abd Elmageed, Zakaria Y; Sholl, Andrew B et al. (2018) Bortezomib sensitizes thyroid cancer to BRAF inhibitor in vitro and in vivo. Endocr Relat Cancer 25:99-109
Ghonim, Mohamed A; Wang, Jeffrey; Ibba, Salome V et al. (2018) Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway. J Transl Med 16:243
Connick, J Patrick; Reed, James R; Backes, Wayne L (2018) Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes. Drug Metab Dispos 46:197-203
Lassak, Adam; Dean, Mathew; Wyczechowska, Dorota et al. (2018) Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival. Mol Cell Biol 38:
Carvalho-Galv√£o, Alynne; Ogunlade, Blessing; Xu, Jiaxi et al. (2018) Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats. Clin Sci (Lond) 132:1513-1527
Berger, Nathan A; Besson, Valerie C; Boulares, A Hamid et al. (2018) Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol 175:192-222
Kharbanda, Kusum K; Ronis, Martin J J; Shearn, Colin T et al. (2018) Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules 8:
Xu, Jiaxi; Sriramula, Srinivas; Lazartigues, Eric (2018) Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons. Cell Mol Neurobiol :
Flanagan, M; Li, C; Dietrich, M A et al. (2018) Downregulation of heat shock protein B8 decreases osteogenic differentiation potential of dental pulp stem cells during in vitro proliferation. Cell Prolif 51:e12420

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