This COBRE III application requests funding to complete the establishment of a free standing, nationally recognized Lung Biology Center (LBC) in the Geisel School of Medicine at Dartmouth. The proposed plan for COBRE III builds upon our successes during COBRE I and II during which time we assembled, from a nucleus of 6 faculty, a critical mass of 32 well funded, tenured and tenure-track principal investigators who conduct inter-/multi-disciplinary research on respiratory infectious diseases. Our LBC faculty share common interests in host-pathogen interactions, the respiratory microbiome, and in drug discovery and therapeutic development. To support the research of our faculty we established three LBC-specific research cores, including a: (1) Host-Pathogen Interaction Core, (2) Live-Cell Imaging Core and (3) Translational Research Core. All of our junior faculty project leaders in COBRE 1/11 have already obtained extramural funding, an impressive record of accomplishment in this funding environment. A COBRE III award will provide essential resources to facilitate the continued development ofthe LBC, provide vital resources to enhance inter/multidisciplinary basic science and translational research in respiratory infectious disease, and is an essential component of our research core business plan to be financially independent by 2018. COBRE III support will enhance the continued mentored development of our junior faculty, including those previously supported by COBRE l/ll, the expansion ofthe research cores and an enhanced Pilot Project Program, and will facilitate mentored, collaborative and/or translational research at Dartmouth. Together with a substantial, and longterm, commitment from Dartmouth and strong collaborative ties with investigators in the Lung Biology and Immunology COBRE programs at the University of Vermont (UVM), the Dartmouth Immunology COBRE, the Dartmouth Quantitative Biological Sciences COBRE, and the INBRE programs at UVM, Dartmouth and the Mt. Desert Island Biological Laboratory (MDIBL) in Maine, we are in an exceptionally strong position to continue to build upon our successes in research on host-pathogen interactions, the respiratory microbiome in CF, and in drug discovery and therapeutic development for respiratory infectious diseases.
Infectious respiratory diseases are the third leading cause of death in the U.S. The studies described in this application will lead to a better understanding of how opportunistic pathogens, including Pseudomonas aeruginosa, cause chronic respiratory infections, and to new drugs / therapies to treat infectious respiratory disease.
|Hogan, Deborah A; Willger, Sven D; Dolben, Emily L et al. (2016) Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease. PLoS One 11:e0149998|
|Cramer, Robert A (2016) In vivo veritas: Aspergillus fumigatus proliferation and pathogenesis--conditionally speaking. Virulence 7:7-10|
|Greene, Casey S; Foster, James A; Stanton, Bruce A et al. (2016) COMPUTATIONAL APPROACHES TO STUDY MICROBES AND MICROBIOMES. Pac Symp Biocomput 21:557-67|
|Obar, Joshua J; Hohl, Tobias M; Cramer, Robert A (2016) New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches. Cytokine 84:63-73|
|Skopelja, Sladjana; Hamilton, B JoNell; Jones, Jonathan D et al. (2016) The role for neutrophil extracellular traps in cystic fibrosis autoimmunity. JCI Insight 1:e88912|
|Dhingra, Sourabh; Kowlaski, Caitlin H; Thammahong, Arsa et al. (2016) RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus. mSphere 1:|
|Caffrey, Alayna K; Obar, Joshua J (2016) Alarmin(g) the innate immune system to invasive fungal infections. Curr Opin Microbiol 32:135-43|
|Kowalski, Caitlin H; Beattie, Sarah R; Fuller, Kevin K et al. (2016) Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence. MBio 7:|
|Kitamura, Seiya; Hvorecny, Kelli L; Niu, Jun et al. (2016) Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa. J Med Chem 59:4790-9|
|Dionne-Odom, Jodie; Massaro, Courtney; Jogerst, Kristen M et al. (2016) Retention in Care among HIV-Infected Pregnant Women in Haiti with PMTCT Option B. AIDS Res Treat 2016:6284290|
Showing the most recent 10 out of 43 publications