The Administrative Core (Core A) will be responsible for the day-to-day operation of the MT COBRE program. The overall goal of the Phase 111 application of the Molecular Targets COBRE (MT COBRE) is to ensure that the novel targets and compounds which have been identified by MT COBRE faculty are translated to pivotal human clinical trials. Under Dr. Miller's direction, Core A will provide budgetary management, core oversight, manage the Pilot Grant Program and monitor progress of the MT COBRE faculty. The MT COBRE Administrative Assistant and the Program Coordinator will report to the MT COBRE PI and co-Director through this core. The Administrative Core will be responsible for organizing all committee meetings including those of the Steering Committee, the Internal Advisory Committee and the External Advisory Committee. It will provide regular evaluations of research core function and fiscal status. Core A also will provide the requisite reports to the NIH Program administration on an annual basis. During the first ten years of MT COBRE funding. Core A has provided very important support to all of the MT COBRE faculty and has played an important role in the overall success of the program. This core will assume an even more important role during Phase III of the COBRE.

Public Health Relevance

Cancer metabolism and cancer drug development are currently very important areas of research. The MT COBRE program has trained leaders in this area;the funding of Phase III will ensure the continued success and growth of the JGBCC core facilities, and thus it's faculty, and this program.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Louisville
United States
Zip Code
Shah, P P; Lockwood, W W; Saurabh, K et al. (2015) Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells. Oncogene 34:1709-17
Zhao, Guoping; Zhu, Yanglong; Eno, Colins O et al. (2014) Activation of the proapoptotic Bcl-2 protein Bax by a small molecule induces tumor cell apoptosis. Mol Cell Biol 34:1198-207
Gray, Robert D; Trent, John O; Chaires, Jonathan B (2014) Folding and unfolding pathways of the human telomeric G-quadruplex. J Mol Biol 426:1629-50
Wilburn, Damien B; Bowen, Kathleen E; Doty, Kari A et al. (2014) Structural insights into the evolution of a sexy protein: novel topology and restricted backbone flexibility in a hypervariable pheromone from the red-legged salamander, Plethodon shermani. PLoS One 9:e96975