Research Pilot Project Program Abstract: The overall goal of the Research Pilot Project Program in the Phase 111 funding cycle is to promote interdisciplinary research in the broad area of cellular signaling, encompassing projects in cell-cell communication, endocytosis and trafficking, biology and therapy of oral cancer, and cancer biology and immunology. Our ongoing research pilot project program, for both individual and collaborative projects, has been extremely successful. Having awarded $827,400 during the first nine years of funding, our program has led to development of multiple external awards totaling over $9.88 million received from NIH and the American Cancer Society. Thus, pilot project funding through the NCCS provides a clear return of over $11 for every dollar invested, without even taking into consideration additional grants arising from the first external funding that benefitted from the pilot funding. Past NCCS pilot projects have either been awarded to single investigators or to collaborating co-investigators. We propose to make a total of $2 million available by awarding four, one-year collaborative pilot grants ($100K) and 16, two-year pilot project grants ($50K per year) during Phase III. The Dean of the UNMC College of Dentistry (COD), the Director of the Eppley Institute (El), and the UNMC Vice Chancellor for Research (VCR) have committed a combined total of $150K per year to supplement NIH funds for NCCS pilot grants during Phase 111. Thus, over the five-year span of Phase III, $1,250K in NIH funds provided by the NCCS will be partnered with $250K each from the COD, Eppley, and the VCR ($750K of combined institutional support, or a 60% match) for this crucial component of the NCCS. Moreover, the Director of the Eppley Institute has pledged a further $50,000 per year for the five years beyond Phase 111, bringing the UNMC commitment to $1 million overall. A rigorous review process for such applications involving review and prioritization of proposals by the NCCS Executive Committee and then critique by the External Advisory Council is already in place to ensure that the projects funded through this mechanism are the most meritorious and have the highest probability of generating the key data needed to compete successfully for external funding. The mechanisms for issuing requests for applications, the proposal review process, notification of awards, evaluation and monitoring of progress on the pilot projects, and follow-up on applications to external funding agencies are described herein.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM106397-01
Application #
8543951
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2013-09-05
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$341,301
Indirect Cost
$101,101
Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Hein, A L; Post, C M; Sheinin, Y M et al. (2016) RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment. Oncogene 35:6319-6329
Bahl, Kriti; Xie, Shuwei; Spagnol, Gaelle et al. (2016) EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides. J Biol Chem 291:13465-78
Chen, Xingcheng; Stauffer, Seth; Chen, Yuanhong et al. (2016) Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis. J Biol Chem 291:14761-72
Cypher, Luke R; Bielecki, Timothy Alan; Huang, Lu et al. (2016) CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface. Cell Signal 28:1325-35
Hua, G; He, C; Lv, X et al. (2016) The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription. Cell Death Dis 7:e2297
Pandey, Poomy; Sliker, Bailee; Peters, Haley L et al. (2016) Amyloid precursor protein and amyloid precursor-like protein 2 in cancer. Oncotarget 7:19430-44
Xie, Shuwei; Bahl, Kriti; Reinecke, James B et al. (2016) The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome. Mol Biol Cell 27:108-26
Case, Adam J; Tian, Jun; Zimmerman, Matthew C (2016) Increased mitochondrial superoxide in the brain, but not periphery, sensitizes mice to angiotensin II-mediated hypertension. Redox Biol 11:82-90
Roberts, Brett J; Svoboda, Robert A; Overmiller, Andrew M et al. (2016) Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. J Biol Chem 291:24857-24865
Zhu, Songli; Peng, Aimin (2016) Non-homologous end joining repair in Xenopus egg extract. Sci Rep 6:27797

Showing the most recent 10 out of 45 publications