Our overall goal is the establishment of a permanent Center for Translational Neuroscience (CTN) dedicated to, a) providing support for maintaining and expanding self-sufficient research cores developed during Phases I and II that are essential for the continuing conduct of basic, clinical, translational, and community based research, and b) sustaining a collaborative, multidisciplinary research environment by providing support for pilot study projects, as well as mentoring and training components. To attain this goal, we designed the following specific aims:
Aim 1 : To enhance the infrastructure critical to the CTN by supporting, upgrading, and streamlining three Core Facilities.
Aim 2 : To strengthen and augment translational mission relevant research through mentoring promising early career clinicians and basic scientists by established, dedicated senior Mentors.
Aim 3 : To expand our successful Career Development Program for CTN investigators and institute a new Leadership Program for established and young researchers, who will be required to meet specific Performance Milestones.
Aim 4 : To support a translational pilot study research program of cutting edge science, promote state wide and additional collaborations within the institution, and create opportunities to develop and maintain competitive research programs.
Aim 5 : To systematically collect, analyze, and use CTN information to answer questions about projects, cores, and policies, especially about their efficiency and effectiveness. An experienced Core Advisory Committee (CAC) will oversee operation and utilization of all the Core Facilities. The External Advisory Committee (EAC) will oversee scientific competitiveness of pilot studies and review progress of the Career Development Program and collaborative research. The Internal Advisory Committee (lAC) will oversee integration of early career investigators and issues related to recruitment, space, and promotion and tenure.
These aims will have a greater impact at a small institution such as ours and facilitate the solidification of a successful and productiv CTN that will set an example for national programs. Our likely success is certified by generating over $30 million in new grant support and publishing over 450 articles and chapters in Phses I and II.

Public Health Relevance

We will create a truly unique translational research center with a realistic possibility of developing novel therapies for ameliorating the deficitis produced y brain disorders. Our efforts have already led to the development of several new therapies and treatments, and to a significant decrease in newborn mortality throughout the state.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110702-01
Application #
8703894
Study Section
Special Emphasis Panel (ZGM1-TWD-C (3C))
Program Officer
Liu, Yanping
Project Start
2014-06-10
Project End
2019-04-30
Budget Start
2014-06-10
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$1,117,500
Indirect Cost
$367,500
Name
University of Arkansas for Medical Sciences
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Fantegrossi, William E; Gray, Bradley W; Bailey, Jessica M et al. (2015) Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT?A receptors, in mice. Psychopharmacology (Berl) 232:1039-47
Mulkey, Sarah B; Swearingen, Christopher J (2014) Advancing neurologic care in the neonatal intensive care unit with a neonatal neurologist. J Child Neurol 29:31-5
Penthala, Narsimha R; Bommagani, Shobanbabu; Janganati, Venumadhav et al. (2014) Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem 85:517-25
Smith, Douglas A; Bailey, Jessica M; Williams, Diarria et al. (2014) Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice. J Pharmacol Exp Ther 351:485-91
Lairamore, Chad I; Garrison, Mark K; Bourgeon, Laetitia et al. (2014) Effects of functional electrical stimulation on gait recovery post-neurological injury during inpatient rehabilitation. Percept Mot Skills 119:591-608
Hyde, James; MacNicol, Melanie; Odle, Angela et al. (2014) The use of three-dimensional printing to produce in vitro slice chambers. J Neurosci Methods 238:82-7
Ziu, Endrit; Hadden, Coedy; Li, Yicong et al. (2014) Effect of serotonin on platelet function in cocaine exposed blood. Sci Rep 4:5945
Hall, Richard W; Anand, Kanwaljeet J S (2014) Pain management in newborns. Clin Perinatol 41:895-924
Yates, Charlotte C; Mitchell, Anita J; Booth, Melissa Y et al. (2014) The effects of massage therapy to induce sleep in infants born preterm. Pediatr Phys Ther 26:405-10