: COBRE Center for Molecular and Tumor Virology ABSTRACT The Center for Molecular and Tumor Virology (CMTV) located at the Louisiana State University Health Sciences Center-Shreveport, University of Louisiana at Monroe, and Louisiana State University-Shreveport in north Louisiana seeks continued support via the COBRE Phase III Program. The multi-institutional CMTV is comprised of 18 faculty members who investigate the structure, genomics, bioinformatics, replication, immunology, and oncogenesis of important animal and human pathogens and their impact on health. The overall objective of this application is to maintain and expand the expertise, mission, and quality of four CMTV Core Facilities that contribute to the research competitiveness of CMTV investigators. The Cores contribute to the ongoing research of the faculty, fellows, and students both within and outside the Center. The research design is multifunctional and will: 1. provide an ongoing Mentoring Program to foster the development of junior and mid-level faculty members who will become competitive for national funding. The methods for mentoring include daily interactions at the bench, CMTV weekly journal club and seminars, a fortnightly research conference of all CMTV members, quarterly meetings of the Mentoring Committee and Internal Advisors to advise junior faculty and assess their progress, interactions with national leaders in virology who will serve as Visiting Scientists, and a yearly Virology Colloquium that includes visits and advice of the External Advisors. 2. promote interdisciplinary and translational research that will expand research at all three campuses and contribute to the productivity of all investigators;A Research Pilot Project Program supplemented by institutional funds will expand and encourage new collaborative research and foster translational and interdisciplinary projects. 3. maintain and manage four Core Facilities that offer equipment, expertise, and state-of-the-art technologies required to address fundamental questions about mechanisms by which viruses replicate, alter the host, and cause disease including cancer. Plans to provide for the operation and support of the CMTV Cores after Phase III are being made, and plans will be implemented to assure that the mission of the CMTV is ongoing after five years of COBRE Phase III funding. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): OCallaghan, Dennis J. Modified Specific Aims

Public Health Relevance

The overall goal of the COBRE Center for Molecular and Tumor Virology (CMTV) is to elucidate the fundamental mechanisms by which viruses alter host cell function, evade the host immune system, and cause disease, including cancer. Accumulation of this information will aid in the design of new vaccines and antiviral drugs to prevent and combat viral infections with the overall hope of eradicating these pathogens. Each of the four Cores and the Pilot Projects Program within the CMTV play a major role in allowing the Center to achieve its goals. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Douthard, Regine
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Louisiana State University Hsc Shreveport
Schools of Medicine
United States
Zip Code
Martinez, Nicholas E; Sato, Fumitaka; Kawai, Eiichiro et al. (2015) Th17-biased ROR?t transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun 43:86-97
Brunson, Jerry L; Becker, Felix; Stokes, Karen Y (2015) The impact of primary and persistent cytomegalovirus infection on the progression of acute colitis in a murine model. Pathophysiology 22:31-7
Kawai, Eiichiro; Sato, Fumitaka; Omura, Seiichi et al. (2015) Organ-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. J Neuroimmunol 278:174-84
Sato, Fumitaka; Omura, Seiichi; Kawai, Eiichiro et al. (2014) Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler's virus infection. Cell Immunol 292:85-93
Omura, Seiichi; Kawai, Eiichiro; Sato, Fumitaka et al. (2014) Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis. Circ Cardiovasc Genet 7:444-54
Martinez, Nicholas E; Sato, Fumitaka; Omura, Seiichi et al. (2014) ROR?t, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol 276:142-9