Abstract

The Mass Spectrometry and Surface Characterization (MSSC) Core is a critical component of COBRE serving the diverse needs of researchers for mass spectrometric and surface characterization of biomaterials. In COBRE 111, the MSSC Core will (1) expand the scope of its instrumentation and scientific capabilities to include analysis of high-molecular weight samples;(2) upgrade and replace the current mass spectrometry instrumentation to maximize the impact of the core for COBRE research;(3) continue to provide support for structural analyses of small-molecule and polymer-based biomaterials.

Public Health Relevance

The ability to develop advanced biomaterials with customized control over morphological, mechanical and biological properties will lead to significant advancement in biomedical fields. The MSSC Core will provide mass spectrometry and surface characterization capabilities needed for the COBRE-based research. These capabilities will enable COBRE investigators to gain comprehensive understanding of the structure of the designed biomaterials and precursors, the knowledge critical to their ability to design biomaterials optimized for their intended biological applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110758-01
Application #
8735399
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C3))
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$140,400
Indirect Cost
$50,400

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Ovadia, Elisa M; Colby, David W; Kloxin, April M (2018) Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells. Biomater Sci 6:1358-1370
Kraus, Jodi; Gupta, Rupal; Yehl, Jenna et al. (2018) Chemical Shifts of the Carbohydrate Binding Domain of Galectin-3 from Magic Angle Spinning NMR and Hybrid Quantum Mechanics/Molecular Mechanics Calculations. J Phys Chem B 122:2931-2939
Williams, Mackenzie G; Teplyakov, Andrew V (2018) Indirect photopatterning of functionalized organic monolayers via copper-catalyzed ""click chemistry"". Appl Surf Sci 447:535-541
Quinn, Caitlin M; Wang, Mingzhang; Polenova, Tatyana (2018) NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology. Methods Mol Biol 1688:1-35
Bush, Timothy S; Yap, Glenn P A; Chain, William J (2018) Transformation of N, N-Dimethylaniline N-Oxides into Diverse Tetrahydroquinoline Scaffolds via Formal Povarov Reactions. Org Lett 20:5406-5409
Hadden, Jodi A; Perilla, Juan R (2018) All-atom virus simulations. Curr Opin Virol 31:82-91
Liu, Jun; Cheng, Rujin; Wu, Haifan et al. (2018) Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl 57:12702-12706
Goodwin, Christopher M; Voras, Zachary E; Beebe Jr, Thomas P (2018) Gas-cluster ion sputtering: Effect on organic layer morphology. J Vac Sci Technol A 36:051507
He, Chuan; Teplyakov, Andrew V (2018) 29,31- H Phthalocyanine Covalently Bonded Directly to a Si(111) Surface Retains Its Metalation Ability. Langmuir 34:10880-10888
Dick, Robert A; Zadrozny, Kaneil K; Xu, Chaoyi et al. (2018) Inositol phosphates are assembly co-factors for HIV-1. Nature 560:509-512

Showing the most recent 10 out of 177 publications