Abstract

The Nuclear Magnetic Resonance (NMR) Core with the existing state-of-the-art instrumentation and techniques is represents a critical part of COBRE to address the following needs of COBRE research programs across the campus ofthe University of Delaware (1) to facilitate the research and development of NMR spectroscopy as a premier method for structural analysis of a wide variety of systems in solution and solid states, and (2) to provide support for structural analyses of small-molecule and macromolecule-based biomaterials in solution and solid states.

Public Health Relevance

Structural characterization of biomaterials at atomic resolution is critical to the design and optimization of biomaterials. Nuclear Magnetic Resonance (NMR) spectroscopy plays a unique and an irreplaceable role as a method for atomic-scale structural analysis ofvarious kinds of materials. The NMR Core will provide stateof- the-art NMR research instrumentation and expertise to help COBRE investigators gain fundamental insights into the structures of materials under investigation. These studies will ultimately generate materials systems that are optimized for their targeted drug delivery and tissue engineering applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM110758-02
Application #
8932714
Study Section
Special Emphasis Panel (ZGM1-TWD-C)
Project Start
Project End
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
2
Fiscal Year
2015
Total Cost
$352,808
Indirect Cost
$126,649

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

DeMeester, Kristen E; Liang, Hai; Jensen, Matthew R et al. (2018) Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J Am Chem Soc 140:9458-9465
Liu, Shuang; Moore, Axel C; Zerdoum, Aidan B et al. (2018) Cellular interactions with hydrogel microfibers synthesized via interfacial tetrazine ligation. Biomaterials 180:24-35
Konh, Mahsa; He, Chuan; Li, Zhengxin et al. (2018) Comparison of ZnO surface modification with gas-phase propiolic acid at high and medium vacuum conditions. J Vac Sci Technol A 36:041404
He, Chuan; Abraham, Baxter; Fan, Hao et al. (2018) Morphology-Preserving Sensitization of ZnO Nanorod Surfaces via Click-Chemistry. J Phys Chem Lett 9:768-772
Liao, Jennie; Guan, Weiye; Boscoe, Brian P et al. (2018) Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C-N Bond Activation. Org Lett 20:3030-3033
Li, Linqing; Stiadle, Jeanna M; Levendoski, Elizabeth E et al. (2018) Biocompatibility of injectable resilin-based hydrogels. J Biomed Mater Res A 106:2229-2242
Lu, Manman; Sarkar, Sucharita; Wang, Mingzhang et al. (2018) 19F Magic Angle Spinning NMR Spectroscopy and Density Functional Theory Calculations of Fluorosubstituted Tryptophans: Integrating Experiment and Theory for Accurate Determination of Chemical Shift Tensors. J Phys Chem B 122:6148-6155
Ovadia, Elisa M; Colby, David W; Kloxin, April M (2018) Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells. Biomater Sci 6:1358-1370
Kraus, Jodi; Gupta, Rupal; Yehl, Jenna et al. (2018) Chemical Shifts of the Carbohydrate Binding Domain of Galectin-3 from Magic Angle Spinning NMR and Hybrid Quantum Mechanics/Molecular Mechanics Calculations. J Phys Chem B 122:2931-2939
Williams, Mackenzie G; Teplyakov, Andrew V (2018) Indirect photopatterning of functionalized organic monolayers via copper-catalyzed ""click chemistry"". Appl Surf Sci 447:535-541

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