Abstract

The COBRE Center in Protein Structure and Function at The University of Kansas is overseen, operated, guided and driven by its Administrative Core. The required roles of Program Director/Principal Investigator, and also that of Program Coordinator, will be filled by Dr. Robert Hanzlik, who was the PD/PI throughout Phase I and Phase II of COBRE-PSF. He will be assisted and advised by a Leadership Committee consisting of the chairs of our three Core Lab Steering Committees (each of whom is a COBRE graduate) and the KU Associate Vice Chancellor for Research (who is also a chemist). An Internal Advisory Committee comprised of a senior faculty member from each of our three partner institutions (KSU, WSU and KUMC), and an External Advisory Committee comprised of four internationally recognized experts in protein structure and function, will also provide advice and guidance. The Administrative Core will implement and oversee a Pilot Project Program, a Writing Program, a Mentoring Program and three continuing and highly successful Core Labs in addition to providing overall leadership for the Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
5P30GM110761-02
Application #
8902222
Study Section
Special Emphasis Panel (ZGM1-TWD-C)
Project Start
Project End
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
2
Fiscal Year
2015
Total Cost
$525,778
Indirect Cost
$175,259

  Institution

Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Murakami, Ryo; Singh, Chingakham Ranjit; Morris, Jacob et al. (2018) The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation. Mol Cell Biol 38:
McGill, Jodi L; Kelly, Sean M; Kumar, Pankaj et al. (2018) Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf. Sci Rep 8:3021
Vasquez-Montes, Victor; Gerhart, Janessa; King, Kelly E et al. (2018) Comparison of lipid-dependent bilayer insertion of pHLIP and its P20G variant. Biochim Biophys Acta Biomembr 1860:534-543
Garabedian, Alyssa; Baird, Matthew A; Porter, Jacob et al. (2018) Linear and Differential Ion Mobility Separations of Middle-Down Proteoforms. Anal Chem 90:2918-2925
Barta, Michael L; Tachiyama, Shoichi; Muthuramalingam, Meenakumari et al. (2018) Using disruptive insertional mutagenesis to identify the in situ structure-function landscape of the Shigella translocator protein IpaB. Protein Sci 27:1392-1406
Kyrychenko, Alexander; Lim, Nathan M; Vasquez-Montes, Victor et al. (2018) Refining Protein Penetration into the Lipid Bilayer Using Fluorescence Quenching and Molecular Dynamics Simulations: The Case of Diphtheria Toxin Translocation Domain. J Membr Biol 251:379-391
Damalanka, Vishnu C; Kim, Yunjeong; Galasiti Kankanamalage, Anushka C et al. (2018) Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease. Eur J Med Chem 143:881-890
Arnett, David C; Bailey, Sheila K; Johnson, Carey K (2018) Exploring the conformations of nitric oxide synthase with fluorescence. Front Biosci (Landmark Ed) 23:2133-2145
Galasiti Kankanamalage, Anushka C; Kim, Yunjeong; Damalanka, Vishnu C et al. (2018) Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. Eur J Med Chem 150:334-346
Lan, Lan; Liu, Hao; Smith, Amber R et al. (2018) Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer 18:809

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