For the past decade, the Oklahoma COBRE GM103456 (previously RR020143) """"""""Molecular Mechanisms and Genetics of Autoimmunity"""""""" has been a pivotal resource in transforming the Oklahoma Medical Research Foundation into an institution committed to the mentoring and development of junior investigators to productive independent scientific careers with an emphasis on the genetics of autoimmune diseases. Through its support of 11 junior investigators, 16 pilot projects, and an evolving set of 3-4 cores, this resource has provided the infrastructure to help launch 11 independent research careers and support the subsequent funding of numerous multi-investigator grants (""""""""program grants"""""""") funded by other NIH institutes. Our Administrative Core will serve as a centralized governing resource for the COBRE, provide adminitstrative assistance and oversight to the research and Pilot cores and serve as a liason between the steering committee, external advisory committee, institutional administration and COBRE investigators. The scientific strategic purpose of the continuation of this COBRE is to support research in the genetics and genomics of autoimmune diseases and begin to broaden our scope of COBRE investigators to other disciplines including cancer, cardiovascular diseases and rare disorders.
The Specific Aims ofthe Administrative core are to 1) coordinate, integrate and fiscally manage to financial independence research cores, which meet and extend the scientific opportunities of our COBRE Investigators, 2) evaluate and manage the effectiveness of research cores and pilot projects, 3) implement and expand multidisciplinary enrichment programs and, 4) assist with grant applications, management and compliance issues.

Public Health Relevance

This OMRF COBRE has been very successful in identifying and facilitating the careers of talented junior investigators. The Administrative Core supports this success through compentent management of overall COBRE operations.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-TWD-C (3C))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oklahoma Medical Research Foundation
Oklahoma City
United States
Zip Code
Leehan, Kerry M; Pezant, Nathan P; Rasmussen, Astrid et al. (2018) Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging. Clin Exp Rheumatol 36 Suppl 112:80-88
Celada, Lindsay J; Kropski, Jonathan A; Herazo-Maya, Jose D et al. (2018) PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-?1 production. Sci Transl Med 10:
Pelikan, Richard C; Kelly, Jennifer A; Fu, Yao et al. (2018) Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks. Nat Commun 9:2905
Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Fu, Yao; Tessneer, Kandice L; Li, Chuang et al. (2018) From association to mechanism in complex disease genetics: the role of the 3D genome. Arthritis Res Ther 20:216
Bagavant, Harini; Dunkleberger, Micah L; Wolska, Nina et al. (2018) Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients. Clin Exp Rheumatol :
Wang, Chih-Chuan; Ortiz-González, Xilma R; Yum, Sabrina W et al. (2018) ?IV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy. Am J Hum Genet 102:1158-1168
Bernatsky, Sasha; Velásquez García, Héctor A; Spinelli, John J et al. (2017) Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus Sci Med 4:e000187
Langefeld, Carl D; Ainsworth, Hannah C; Cunninghame Graham, Deborah S et al. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8:16021
Aberle, Teresa; Bourn, Rebecka L; Chen, Hua et al. (2017) Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med 4:e000176

Showing the most recent 10 out of 32 publications