The goal of the Nebraska Center for the Molecular Biology of Neurosensory Systems (NCNS) is to build a producfive group of researchers invesfigafing the mechanisms of neurosensory development which will provide the foundafions for new treatments. The Administrafive Core is designed to provide the infrastructure required to attain the research and infrastructure goals of the NCNS. The structures and services in the core are designed to promote the confinued growth of neurosensory and neurodeveiopmental research through 1) oversight of effective and efficient scientific cores;2) direcfion of programs to provide support;3) mentoring for pilot research;and 4) coordination with other COBRE and INBRE programs. The Administrafive Core is led by the Principal Investigator, who directs the scientific and research,mission of the NCNS, and the Program Coordinator who provides guidance and oversight for the four scientific core facilties. The PI is assisted by representafives from the two participafing insfitufions, Boys Town Nafional Research Hospital and Creighton University, forming the Execufive Committee. An internal Steering Committee is established to advise the PI in policy decisions and in the selecfion of research projects and to provide an annual evaluation. An External Advisory Committee of prominent scienfists provides further expert evaluafion for the NCNS. Our research and mentoring efforts have resulted in the development of an interactive group of productive junior and senior researchers. Our core facilities are widely used and have proven to be essential to the biomedical research enterprise at our three cooperating institutions. The continued operafion ofthe cores beyond the funding period will be assured through the application of efficient management tools in each core and the commitment of the administrative officials from all three institutions.

Public Health Relevance

Research into the causes of neurodeveiopmental disorders such as hearing loss, vision loss, and aufism is necessary for the discovery of effective biomedical treatments. The Administrafive core provides the infrastructure for support and mentoring of researchers and for the building of efficient state-of-the-art core facilities. Internal and external evaluafions assure that the administrafion operates effecfively.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZGM1-TWD-C (3C))
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University of Nebraska Medical Center
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Ka, Minhan; Chopra, Divyan A; Dravid, Shashank M et al. (2016) Essential Roles for ARID1B in Dendritic Arborization and Spine Morphology of Developing Pyramidal Neurons. J Neurosci 36:2723-42
Dufek, Brianna; Meehan, Daniel T; Delimont, Duane et al. (2016) Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease. Kidney Int 90:300-10
Gurumurthy, Channabasavaiah B; Takahashi, Gou; Wada, Kenta et al. (2016) GONAD: A Novel CRISPR/Cas9 Genome Editing Method that Does Not Require Ex Vivo Handling of Embryos. Curr Protoc Hum Genet 88:Unit 15.8
Ka, Minhan; Kim, Woo-Yang (2016) Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain. Mol Neurobiol 53:6018-6032
Yilmazer-Hanke, Deniz; O'Loughlin, Elaine; McDermott, Kieran (2016) Contribution of amygdala pathology to comorbid emotional disturbances in temporal lobe epilepsy. J Neurosci Res 94:486-503
Meehan, Daniel T; Delimont, Duane; Dufek, Brianna et al. (2016) Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. Hear Res 341:100-108
Schulze, Thomas T; Ali, Jonathan M; Bartlett, Maggie L et al. (2016) De novo Assembly and Analysis of the Chilean Pencil Catfish Trichomycterus areolatus Transcriptome. J Genomics 4:29-41
Wong, Chuu-Yun A; Jiang, Haihong; Abel, Peter W et al. (2016) Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression. Protein Cell 7:445-9
Sato, Masahiro; Ohtsuka, Masato; Watanabe, Satoshi et al. (2016) Nucleic acids delivery methods for genome editing in zygotes and embryos: the old, the new, and the old-new. Biol Direct 11:16
Kristensen, Anders S; Hansen, Kasper B; Naur, Peter et al. (2016) Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Mol Pharmacol 89:253-62

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