The Cell Biology Core (CBC) within the Center for Evolutionary and Theoretical Immunology (CETI) was established in Phase II with Dr. Charies Cunningham named as Director. The CBC was established in response to the needs of newly-hired principal investigators and was facilitated by the acquisition of new CETI building space acquired at that time. CBC equipment items purchased in Phase II with COBRE funds include an inverted Nikon Ti fluorescent microscope, a Microm HM550 cryostat, and an Attune acoustic focusing flow cytometer. The core has also acquired from non-COBRE sources a Zeiss confocal microscope. As part of the CBC's first aim in Phase III, to further expand the CBC's capabilities and improve the microscopy facilities of the core, a Nikon high-resolution color camera will be purchased for the Nikon fluorescent microscope. The CBC's second aim is to purchase a BD Biosciences FACSAria II Cell Sorter to complement the flow cytometry functions already in place. In addition, a full-time technician will be hired to assist the core director with providing both enhanced microscopy and cell-sorting functions, thereby helping to fulfill the aims of the CBC.
The third aim of the CBC is to develop and provide all the services needed for core users to maximize their likelihood of securing extramural funding and achieving long-term career success. This includes integrating the CBC into the Administrative Core's steering committee and CETI's Pilot Project and Waiver programs, including associated mentoring for users. The CBC's final aim is to develop and implement a business model that will transition the CBC to financial independence by the end of Phase III. After fully staffing and equipping the CBC in years one and two, accompanied by an outreach program to increase the CBC's user base, the CBC will begin to transition to cost neutrality in year three with the assistance of pilot project and waiver awards. Finally, thanks to the support received from the UNM administration, additional pilot project awards and equipment service contract funds will continue to be made to the CBC post-Phase III, in years sixteen through twenty of CETI's existence. An expanded and fully staffed CBC will provide essential new resources for our investigators, increase their likelihood of securing funding, and thus fulfill the goals ofthe IDeA program.

Public Health Relevance

This core, by providing key scientific infrastructure, mentoring and financial support to investigators in New Mexico, will help them to be more competitive for securing extramural funding. Ultimately, this will help fulfill one of the major goals of the IDeA program, namely to help under-funded states like New Mexico be more competitive. The CBC will also favor scientific discoveries of both basic and applied nature in the field of immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM110907-01
Application #
8751178
Study Section
Special Emphasis Panel (ZGM1-TWD-C (3C))
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$97,913
Indirect Cost
$27,802
Name
University of New Mexico
Department
Type
DUNS #
868853094
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Dahari, Harel; Cotler, Scot J; Feld, Jordan J (2016) Cure prevents more than transmission of HCV. Hepatology :
Canini, Laetitia; Guedj, Jeremie; Chatterjee, Anushree et al. (2016) Modelling the interaction between danoprevir and mericitabine in the treatment of chronic HCV infection. Antivir Ther 21:297-306
Krasnec, Katina V; Papenfuss, Anthony T; Miller, Robert D (2016) The UT family of MHC class I loci unique to non-eutherian mammals has limited polymorphism and tissue specific patterns of expression in the opossum. BMC Immunol 17:43
McLean, Nancy Johnstone; Newkirk, Kimberly; Adema, Coenraad M (2016) Canine ocular onchocerciasis: a retrospective review of the diagnosis, treatment, and outcome of 16 cases in New Mexico (2011-2015). Vet Ophthalmol :
Tavalire, Hannah F; Blouin, Michael S; Steinauer, Michelle L (2016) Genotypic variation in host response to infection affects parasite reproductive rate. Int J Parasitol 46:123-31
Larragoite, Erin T; Tacchi, Luca; LaPatra, Scott E et al. (2016) An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery. Fish Shellfish Immunol 49:351-4
Zhang, Si-Ming; Loker, Eric S; Sullivan, John T (2016) Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata. Dev Comp Immunol 56:25-36
Lu, Lijun; Zhang, Si-Ming; Mutuku, Martin W et al. (2016) Relative compatibility of Schistosoma mansoni with Biomphalaria sudanica and B. pfeifferi from Kenya as assessed by PCR amplification of the S. mansoni ND5 gene in conjunction with traditional methods. Parasit Vectors 9:166
Elwell, Jennifer A; Lovato, TyAnna L; Adams, Melanie M et al. (2015) The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm. Dev Biol 400:266-76
Zhang, Si-Ming; Buddenborg, Sarah K; Adema, Coen M et al. (2015) Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide. PLoS Negl Trop Dis 9:e0004131

Showing the most recent 10 out of 48 publications