The University of Washington's Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary research program in the field of intellectual/developmental disabilities and related aspects of human development. Research is carried out in three major domains: (1) Developmental and Molecular Genetics, (2) Developmental Neuroscience, and (3) Developmental Processes and Behavioral Science. Interdisciplinary collaborations are emphasized in research carried out in 12 Research Emphasis Areas;Autism, Craniofacial Malformations, Developmental Toxicology, Ecological Factors, Fetal Alcohol Syndrome, Fragile X Syndrome, Infectious Disease and Immunology, Joubert Syndrome, Learning Disabilities, Neurodegenerative Disorders, Neurodevelopmental Oncology, and Neuroinflammation. Through this grant mechanism, support is requested for six scientific core facilities and one administrative core to enhance the effectiveness of scientists carrying out their research as part of the IDDRC. The scientific core support facilities are as follows: (1) Genetics, (2) Brain Imaging, (3) Cellular Morphology, (4) Behavioral Science, (5) Infant Primate Research Laboratory, and (6) Instrument Development Laboratory. Other IDDRC objectives include training researchers in various disciplines, disseminating research findings, and maintaining linkages to clinical training activities and exemplary service programs.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-MRG-C (16))
Program Officer
Parisi, Melissa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Organized Research Units
United States
Zip Code
Su, Z; Wang, X; Gao, X et al. (2014) Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med 276:470-85
Mason, Amanda G; Tome, Stephanie; Simard, Jodie P et al. (2014) Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Hum Mol Genet 23:1606-18
Wang, Wenbin; Pan, Yung-Wei; Zou, Junhui et al. (2014) Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci 34:2130-47
Careaga, Milo; Noyon, Tamanna; Basuta, Kirin et al. (2014) Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation 11:110
Basuta, K; Lozano, R; Schneider, A et al. (2014) A family with two female siblings with compound heterozygous FMR1 premutation alleles. Clin Genet 85:458-63
Su, Wei; Hopkins, Stephanie; Nesser, Nicole K et al. (2014) The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. J Immunol 192:358-66
Tassone, Flora (2014) Newborn screening for fragile X syndrome. JAMA Neurol 71:355-9
Cooke, Cheryl L; Bowie, Bonnie H; Carrère, Sybil (2014) Perceived discrimination and children's mental health symptoms. ANS Adv Nurs Sci 37:299-314
Vanderhoeven, Jeroen P; Bierle, Craig J; Kapur, Raj P et al. (2014) Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening. PLoS Pathog 10:e1003920
Naydenov, Alipi V; Horne, Eric A; Cheah, Christine S et al. (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83:361-71

Showing the most recent 10 out of 140 publications