The Infant Primate Research Laboratory (IPRL) is supported as a Core facility of both the Center on Human Development and Disability (CHDD) and the Washington National Primate Research Center (WaNPRC). For over 30 years, the overall objective of this Core has been to provide a range of technical services, equipment, and facilifies to CHDD Research Affiliates using nonhuman primates in research related to children's health and developmental disabilities. Research projects in past years focused on important topics including fetal alcohol syndrome, pediatric AIDS, and premature birth or low-birth weight. Current projects continue to address important issues such as the developmental consequences of early therapeufic drug exposures, intervenfion strategies for anoxia at birth, and the prevention of premature delivery related to maternal infecfion. These studies are complex and take years to complete. Recent grant awards to CHDD Research Affiliates have indicated that the services and expertise provided by the IPRL are a crifical element for the success of their projects.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Su, Z; Wang, X; Gao, X et al. (2014) Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med 276:470-85
Mason, Amanda G; Tome, Stephanie; Simard, Jodie P et al. (2014) Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Hum Mol Genet 23:1606-18
Wang, Wenbin; Pan, Yung-Wei; Zou, Junhui et al. (2014) Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J Neurosci 34:2130-47
Careaga, Milo; Noyon, Tamanna; Basuta, Kirin et al. (2014) Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome. J Neuroinflammation 11:110
Basuta, K; Lozano, R; Schneider, A et al. (2014) A family with two female siblings with compound heterozygous FMR1 premutation alleles. Clin Genet 85:458-63
Su, Wei; Hopkins, Stephanie; Nesser, Nicole K et al. (2014) The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. J Immunol 192:358-66
Tassone, Flora (2014) Newborn screening for fragile X syndrome. JAMA Neurol 71:355-9
Cooke, Cheryl L; Bowie, Bonnie H; Carrère, Sybil (2014) Perceived discrimination and children's mental health symptoms. ANS Adv Nurs Sci 37:299-314
Vanderhoeven, Jeroen P; Bierle, Craig J; Kapur, Raj P et al. (2014) Group B streptococcal infection of the choriodecidua induces dysfunction of the cytokeratin network in amniotic epithelium: a pathway to membrane weakening. PLoS Pathog 10:e1003920
Naydenov, Alipi V; Horne, Eric A; Cheah, Christine S et al. (2014) ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 83:361-71

Showing the most recent 10 out of 140 publications