This Core, renamed from the Design and Statistical Computing Core to the Data Management and Statistical Analysis (DMSA) Core, has been part of the UNC Mental Retardation Research Center since 1987, and now also includes access to expertise related to the microarray gene expression added to the UNC DDRC in 2003. The overall objectives of the DMSA Core are to enhance the productivity of UNC DDRC investigators and to enhance the quality of their research. We achieve these objectives by collaborating with investigators, providing them with services through every stage of a research project. We participate in writing grant proposals, developing efficient experimental designs, designing data collection instruments, conducting pilot tests, designing and implementing database management systems, supervising execution of the study and collection of data, operating database management systems to clean, store, and retrieve data, performing statistical analyses, writing research papers and reports, and archiving databases. To each phase of the research effort we contribute the unique perspectives and experiences of psychometricians, biostatisticians, professionally trained research database managers, and a support staff of proficient programmers and data managers. Our efforts regarding both traditional data management and analysis and bioinformatics have been integrated into the UNC DDRC. Drs. Burchinal, Gu, Poe, and Zu have been consistent co-authors in publication and Drs. Burchinal, Wright, Gu, Poe, and Neebe have been co-investigators on UNC DDRC projects.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
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Special Emphasis Panel (ZHD1-MRG-C)
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University of North Carolina Chapel Hill
Chapel Hill
United States
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Klusek, Jessica; Schmidt, Joseph; Fairchild, Amanda J et al. (2017) Altered sensitivity to social gaze in the FMR1 premutation and pragmatic language competence. J Neurodev Disord 9:31
Movaghar, Arezoo; Mailick, Marsha; Sterling, Audra et al. (2017) Automated screening for Fragile X premutation carriers based on linguistic and cognitive computational phenotypes. Sci Rep 7:2674
Wheeler, Anne; Raspa, Melissa; Hagerman, Randi et al. (2017) Implications of the FMR1 Premutation for Children, Adolescents, Adults, and Their Families. Pediatrics 139:S172-S182
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16
Wilson, Kaitlyn P; Carter, Mary W; Wiener, Heather L et al. (2017) Object play in infants with autism spectrum disorder: A longitudinal retrospective video analysis. Autism Dev Lang Impair 2:
DuBay, Michaela; Watson, Linda R; Zhang, Wanqing (2017) In Search of Culturally Appropriate Autism Interventions: Perspectives of Latino Caregivers. J Autism Dev Disord :
Swanson, Meghan R; Wolff, Jason J; Elison, Jed T et al. (2017) Splenium development and early spoken language in human infants. Dev Sci 20:
Martin, Gary E; Barstein, Jamie; Hornickel, Jane et al. (2017) Signaling of noncomprehension in communication breakdowns in fragile X syndrome, Down syndrome, and autism spectrum disorder. J Commun Disord 65:22-34
Komesidou, Rouzana; Brady, Nancy C; Fleming, Kandace et al. (2017) Growth of Expressive Syntax in Children With Fragile X Syndrome. J Speech Lang Hear Res 60:422-434
Hahn, Laura J; Brady, Nancy C; McCary, Lindsay et al. (2017) Early social communication in infants with fragile X syndrome and infant siblings of children with autism spectrum disorder. Res Dev Disabil 71:169-180

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