We seek continued support for the Waisman Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program on IDD spanning the biological, biobehavioral, and behavioral sciences. The Waisman IDDRC brings together 49 PIs from 25 academic departments from the UW-Madison Schools of Medicine and Public Health, Veterinary Medicine, Pharmacy, Agriculture and Life Sciences, Letters and Science, Education, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, and biostatistical and bioinformatics expertise;ad four innovative scientific core services: Research Participation (Core B), providing services, resources, and training in the recruitment of human participants, clinical assessment, and behavioral methods development;Brain Imaging (Core C), providing access to state-of-the-art neuroimaging instrumentation (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, and an EEG recording system), as well as expertise and tools for image acquisition and analysis;Rodent Models (Core D), providing resources, expertise, and technical services in the generation, cryopreservation, and maintenance of mutant or genetically engineered strains of mice, and advanced behavioral testing facilities for phenotypic characterization;and Cellular and Molecular Neuroscience (Core E), providing cellular and molecular neuroscience technology, training, and expertise, and supporting the generation of iPS cell lines from humans with IDD conditions. We propose to provide core support to 95 research projects headed by 49 PIs organized into three research groups: Molecular and Genetic Sciences, Communicative and Cognitive Sciences, and Social and Affective Sciences. Collectively, the core services and research groups of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations, sharpening our focus on discovery, prevention, and treatment for IDD conditions and improvement of the quality of life of individuals with IDD and their families.

Public Health Relevance

The mission of the Waisman IDDRC is to promote the highest level of IDD research by providing access to cutting-edge and efficient core services, seminars, and pre- and post-doctoral training via a comprehensive program designed to produce a transformative understanding of IDD pathology, development of new therapies, and training the next generation of basic and clinical IDD researchers.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-Y (50))
Program Officer
Parisi, Melissa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
Other Domestic Higher Education
United States
Zip Code
Hanson, Jamie L; Nacewicz, Brendon M; Sutterer, Matthew J et al. (2015) Behavioral problems after early life stress: contributions of the hippocampus and amygdala. Biol Psychiatry 77:314-23
Hay, Jessica F; Graf Estes, Katharine; Wang, Tianlin et al. (2015) From flexibility to constraint: the contrastive use of lexical tone in early word learning. Child Dev 86:22-Oct
Woodman, Ashley C; Smith, Leann E; Greenberg, Jan S et al. (2015) Change in autism symptoms and maladaptive behaviors in adolescence and adulthood: the role of positive family processes. J Autism Dev Disord 45:111-26
Kan, Alan; Litovsky, Ruth Y (2015) Binaural hearing with electrical stimulation. Hear Res 322:127-37
Romens, Sarah E; McDonald, Jennifer; Svaren, John et al. (2015) Associations between early life stress and gene methylation in children. Child Dev 86:303-9
Taylor, Julie Lounds; Smith, Leann E; Mailick, Marsha R (2014) Engagement in vocational activities promotes behavioral development for adults with autism spectrum disorders. J Autism Dev Disord 44:1447-60
Woodman, Ashley C; Mawdsley, Helena P; Hauser-Cram, Penny (2014) Parenting stress and child behavior problems within families of children with developmental disabilities: Transactional relations across 15 years. Res Dev Disabil 36C:264-276
Finestack, Lizbeth H (2014) Language learning of children with typical development using a deductive metalinguistic procedure. J Speech Lang Hear Res 57:509-23
Johnson, Sterling C; Christian, Bradley T; Okonkwo, Ozioma C et al. (2014) Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiol Aging 35:576-84
Kover, Sara T; Haebig, Eileen; Oakes, Ashley et al. (2014) Sentence comprehension in boys with autism spectrum disorder. Am J Speech Lang Pathol 23:385-94

Showing the most recent 10 out of 440 publications