The Rodent Models Core is essential to the success of IDDRC projects that use rodent models for the study of normal and abnormal development and degeneration of the nervous system. The Rodent Models Core provides technical support for the generation and characterization of transgenic, knock-out, and knock-in strains of mice, access to sophisticated shared behavioral equipment, and expertise in the behavioral phenotyping of mouse and rat models of IDD and related disorders. The Rodent Models Core was rated """"""""outstanding"""""""" in the review from 2005, while being in the midst of planning for a major renovation and introduction of entirely new services (i.e., behavioral testing). The Core was highly rated for its leadership (""""""""This application was written with impressive insights into research needs, and great attention to detail'), planning of the new design (""""""""Barrier, non-barrier, and quarantine rooms are now in abundance, with thorough security and thoughtful facility management'), and support for research. However, questions were voiced in two areas: 1) the interim status of the renovation and facility management staffing (the overall summary commented that """"""""a degree of uncertainty remains with the Rodent Models Core, since the person who will manage the core has not yet been hired, and the facility is not yet completed') and 2) the prediction that we would have difficulty hiring a PhD level staff member for the behavioral testing service and the mistaken impression that only two investigators would actually make use of the behavioral facility. Five years later, we believe we have successfully met all of our milestones. The renovation was completed with creation of a dedicated suite for behavioral testing, acquisition of major equipment, and upgrade of infrastructure, transforming the RMC into a barrier facility. All staff, including the facility manager and PhD level psychologist for the Behavioral Testing Suite, were hired, trained, and are now stable members of the Waisman IDDRC core staff. The RMC is now an outstanding resource that is central to the scientific programs of 16 IDDRC investigators.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD003352-48
Application #
8734265
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
48
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
City
Madison
State
WI
Country
United States
Zip Code
53715
Ellis Weismer, Susan; Davidson, Meghan M; Gangopadhyay, Ishanti et al. (2017) The role of nonverbal working memory in morphosyntactic processing by children with specific language impairment and autism spectrum disorders. J Neurodev Disord 9:28
Simmering, Vanessa R; Wood, Chelsey M (2017) The development of real-time stability supports visual working memory performance: Young children's feature binding can be improved through perceptual structure. Dev Psychol 53:1474-1493
Lundwall, Rebecca A; Dannemiller, James L; Goldsmith, H Hill (2017) Genetic associations with reflexive visual attention in infancy and childhood. Dev Sci 20:
Bishop-Fitzpatrick, Lauren; Minshew, Nancy J; Mazefsky, Carla A et al. (2017) Perception of Life as Stressful, Not Biological Response to Stress, is Associated with Greater Social Disability in Adults with Autism Spectrum Disorder. J Autism Dev Disord 47:1-16
Dean 3rd, Douglas C; Hurley, Samuel A; Kecskemeti, Steven R et al. (2017) Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease. JAMA Neurol 74:41-49
Potter, Christine E; Saffran, Jenny R (2017) Exposure to multiple accents supports infants' understanding of novel accents. Cognition 166:67-72
Potter, Christine E; Wang, Tianlin; Saffran, Jenny R (2017) Second Language Experience Facilitates Statistical Learning of Novel Linguistic Materials. Cogn Sci 41 Suppl 4:913-927
Betthauser, Tobey J; Lao, Patrick J; Murali, Dhanabalan et al. (2017) In Vivo Comparison of Tau Radioligands 18F-THK-5351 and 18F-THK-5317. J Nucl Med 58:996-1002
Hustad, Katherine C; Allison, Kristen M; Sakash, Ashley et al. (2017) Longitudinal development of communication in children with cerebral palsy between 24 and 53 months: Predicting speech outcomes. Dev Neurorehabil 20:323-330
Chan, Wai; Smith, Leann E; Greenberg, Jan S et al. (2017) Executive Functioning Mediates the Effect of Behavioral Problems on Depression in Mothers of Children With Developmental Disabilities. Am J Intellect Dev Disabil 122:11-24

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