Fundamental issues in biology are how the brain develops and how its interactions with the environment influence behavior. The Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of Massachusetts Medical School addresses these issues through wide-ranging programs of research on both typical and atypical development, which include biomedical, biobehavioral, and behavioral science dimensions relevant to intellectual and developmental disabilities. The IDDRC and its companion University Center for Excellence in Developmental Disabilities also train professionals for careers in research and service to people with IDD and their families. UMMS IDDRC research interests include (1) understanding biological processes that occur during development of the nervous system;(2) characterizing molecular defects in genetic disorders which affect the nervous system;(3) establishing the genetic basis of neurodevelopmental disorders and potentially related neuropsychiatric and neurodegenerative disorders;(4) identifying brain regions and functional neural systems that may be involved in IDD;(5) advancing knowledge of fundamental processes involved in learning, perception, language, and cognition;(6) applying that knowledge to improve the educational opportunities for persons with IDD;and (7) promoting healthy lifestyles for persons with IDD and their families. Four core units are proposed to encourage research responsive to the NICHD priorities listed in RFA HD-09-012: (A) Administration, Communications, and Mentorship;(B) Basic Neurobiology Research Support;(C) Quantitative Methodologies, and (D) Clinical and Translational Research Support. Each core unit features state-of-the-art equipment, facilities, and/or problem-solving capability, and each gives high quality, cost-effective service to a variety of PHS-funded projects. The collective operations of the cores will both enhance existing IDD research and stimulate new interdisciplinary and translational research in IDD at UMMS and its affiliated institutions.

Public Health Relevance

The IDD Research Center at the University of Massachusetts conducts a comprehensive program of research, training, and service relevant to the needs of people with intellectual and developmental disabilities and their families. Research programs supported by this program are directed at better understanding of such disabilities and better methods for preventing them and/or reducing their impact on individuals and society.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD004147-41
Application #
8501583
Study Section
Special Emphasis Panel (ZHD1-MRG-C (ID))
Program Officer
Parisi, Melissa
Project Start
1997-08-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
41
Fiscal Year
2013
Total Cost
$789,212
Indirect Cost
$309,448
Name
University of Massachusetts Medical School Worcester
Department
Pediatrics
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Eicher, John D; Montgomery, Angela M; Akshoomoff, Natacha et al. (2016) Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children. Brain Imaging Behav 10:272-82
Farber, Rachel S; Dube, William V; Dickson, Chata A (2016) A sorting-to-matching method to teach compound matching to sample. J Appl Behav Anal 49:294-307
Dube, William V; Farber, Rachel S; Mueller, Marlana R et al. (2016) Stimulus Overselectivity in Autism, Down Syndrome, and Typical Development. Am J Intellect Dev Disabil 121:219-35
Stanish, Heidi I; Curtin, Carol; Must, Aviva et al. (2016) Physical Activity Enjoyment, Perceived Barriers, and Beliefs Among Adolescents With and Without Intellectual Disabilities. J Phys Act Health 13:102-10
Curtin, Carol; Bandini, Linda G; Must, Aviva et al. (2016) Including Youth with Intellectual Disabilities in Health Promotion Research: Development and Reliability of a Structured Interview to Assess the Correlates of Physical Activity among Youth. J Appl Res Intellect Disabil 29:378-86
Jernigan, Terry L; Brown, Timothy T; Hagler Jr, Donald J et al. (2016) The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. Neuroimage 124:1149-54
Curtin, Carol; Humphrey, Kristin; Vronsky, Kaela et al. (2016) Expanding Horizons: A Pilot Mentoring Program Linking College/Graduate Students and Teens With ASD. Clin Pediatr (Phila) 55:150-6
Thapar, A; Martin, J; Mick, E et al. (2016) Psychiatric gene discoveries shape evidence on ADHD's biology. Mol Psychiatry 21:1202-7
Du, Jiang; Quan, Meina; Zhuang, Wenxu et al. (2015) Hippocampal volume reduction in female but not male recent abstinent methamphetamine users. Behav Brain Res 289:78-83
Schlichenmeyer, Kevin J; Dube, William V; Vargas-Irwin, Mariela (2015) Stimulus Fading and Response Elaboration in Differential Reinforcement for Alternative Behavior. Behav Interv 30:51-64

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