Abstract

This proposal provides central support for research in Mental Retardation at UCLA. The Mental Retardation Research Center (MRRC) at UCLA is a multi-funded, interdisciplinary research and teaching program which has the following objectives: Research into problems of mental retardation and related aspects of human development. Research training, at the pre- and postdoctoral levels, of specialists in a variety of disciplines related to our goals. Studies fall into the following categories: Developmental Biology, Neurobiochemistry, Neurophysiology, Behavioral Studies. An emphasis in indicated on applied research. Collaborative relationships are maintained with other UCLA programs in the Neuropsychiatric Institute, and Brain Research Institute, various departments of the School of Medicine, and other schools at UCLA. This application requests funds for administrative and common research support in Core facilities; Administration, New Program Development, Molecular Biology, Neural Cell Culture, Neurohistology, Microcomputers and Media, Statistics and Electronics and Vivarium.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD004612-24
Application #
2194862
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1990-08-01
Project End
1995-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
24
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Ago, Yukio; Hayata-Takano, Atsuko; Kawanai, Takuya et al. (2017) Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiol Learn Mem 145:222-231
Yvone, Griselda M; Zhao-Fleming, Hannah H; Udeochu, Joe C et al. (2017) Disabled-1 dorsal horn spinal cord neurons co-express Lmx1b and function in nociceptive circuits. Eur J Neurosci 45:733-747
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:431-49
Espinosa-Jeffrey, Araceli; Blanchi, Bruno; Biancotti, Juan Carlos et al. (2016) Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes. Curr Protoc Stem Cell Biol 38:2D.18.1-2D.18.27
Condro, Michael C; Matynia, Anna; Foster, Nicholas N et al. (2016) High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons. J Comp Neurol 524:3827-3848
Espinosa-Jeffrey, Araceli; Nguyen, Kevin; Kumar, Shalini et al. (2016) Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism. J Neurosci Res 94:1434-1450
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:1844
Abad, Catalina; Jayaram, Bhavaani; Becquet, Laurine et al. (2016) VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 13:169
Khankan, Rana R; Griffis, Khris G; Haggerty-Skeans, James R et al. (2016) Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration. J Neurosci 36:6269-86

Showing the most recent 10 out of 82 publications