The UCLA MRRC provides a comprehensive multidisciplinary research program in the field of mental retardation and related aspects of human development. The research activities of the Center are directed towards understanding the basic mechanisms of normal and aberrant.neurobiological development, addressing all of the 20 research priorities listed in the FRA issued by NICHD) for Mental Retardation Research Centers. The long term goals of the Center are to discover ways to prevent mental retardation and to improve the quality of life for mentally retarded and other developmentally disabled individuals. To accomplish this, research is carried out by five organized research groups: Clinical Research, Developmental Biology, Neurobiochemistry, Neurophysiology, and Socio- behavioral studies. The research projects are supported by 6 scientific cores and three general service cores: (l) Molecular Biology, (2) Cell Culture and Microinjection, (3) Neurohistology,. (4) Confocal Microscopy, Qualitative and Quantitative Imaging, (S) Field Work Training, (6) Statistics,(7) Microcomputers/ Media, (8) Technical Services, and (9) Administrative. The function of the Center is to provide an environment promoting the highest level of research in mental retardation at UCLA. The Center will foster interaction among UCLA investigators and facilitate their research through the use of efficient and cost effective core services. The Center assigns high priority to the support of talented young investigators and the training of pre- and postdoctoral fellows in a variety of disciplines related to its goals.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD004612-25
Application #
2194863
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1990-08-01
Project End
2000-07-31
Budget Start
1995-09-22
Budget End
1996-07-31
Support Year
25
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Ago, Yukio; Hayata-Takano, Atsuko; Kawanai, Takuya et al. (2017) Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiol Learn Mem 145:222-231
Yvone, Griselda M; Zhao-Fleming, Hannah H; Udeochu, Joe C et al. (2017) Disabled-1 dorsal horn spinal cord neurons co-express Lmx1b and function in nociceptive circuits. Eur J Neurosci 45:733-747
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:431-49
Espinosa-Jeffrey, Araceli; Blanchi, Bruno; Biancotti, Juan Carlos et al. (2016) Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes. Curr Protoc Stem Cell Biol 38:2D.18.1-2D.18.27
Condro, Michael C; Matynia, Anna; Foster, Nicholas N et al. (2016) High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons. J Comp Neurol 524:3827-3848
Espinosa-Jeffrey, Araceli; Nguyen, Kevin; Kumar, Shalini et al. (2016) Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism. J Neurosci Res 94:1434-1450
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:1844
Abad, Catalina; Jayaram, Bhavaani; Becquet, Laurine et al. (2016) VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 13:169
Khankan, Rana R; Griffis, Khris G; Haggerty-Skeans, James R et al. (2016) Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration. J Neurosci 36:6269-86

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