The use of genetically-engineered mice and rats (e.g. transgenic, knock-out, knock-in, conditional transgenic, etc.) as animal models has become widespread in almost all aspects of biology. In many of the projects carried out by scientists within the IDDRC, genetically-engineered mice or rats are being used as animal models to determine the function of genes, fundamental biological mechanisms of cell/tissue function, and/or to use as animal models of disease or behavioral abnormalities. These animals have either been generated here at UCLA or they have been imported from other institutions and used to establish local breeding colonies. With this large increase in the availability and use of transgenic animals, there is a concomitant need for core services to help individual scientists create, breed, import, genotype and evaluate mouse and rat lines. Many, if not most, of the scientists obtaining these mice have not had to deal with breeding and genotyping of such animals before. Nonetheless, they need to be able to take advantage of these animal models to extend their research effort into important new areas. For these reasons, we have set up Core services to educate investigators about and perform these activities. The nature of the services for investigators will vary in their degree of sophistication and Core involvement for each investigator will depend upon the needs of individual laboratories.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD004612-43
Application #
8516546
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
2013-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
43
Fiscal Year
2013
Total Cost
$152,282
Indirect Cost
$60,909
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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