This Center grant requests funding for seven Core facilities and one Subcore;Administrative with Translational Neuroscience Subcore, Proteomics, Cellular Imaging, Neurodevelopmental Behavioral, Mouse Gene Manipulation, Molecular Genetics and Stem Cell, to support a broadly-based research program in intellectual and developmental disabilities at Children's Hospital Boston and Harvard Medical School.
Our specific aims are to: 1) Maintain and introduce new """"""""state of the art"""""""" core facilities that can be shared by Intellectual and Developmental Disabilities Research Center (IDDRC) investigators, providing core research services not possible in a single laboratory;2) Use the framework of the core laboratories to enhance and encourage collaboration between IDDRC investigators;3) Provide core services to aid in the training of young investigators and trainees and 4) Use the core services provided by the IDDRC program to leverage collaboration outside the institution, particularly with other IDDRCs, to speed the development of effective clinical interventions in intellectual and developmental disabilities. The Center supports 124 research projects and 77 investigators who receive approximately $75M in external funding, $57M of which is from the NIH. Research in the Center occurs in over 142,000 sq.ft. of space in research buildings at Children's Hospital Boston and Harvard Medical School affiliated institutions in the Harvard Longwood Medical Area. Our research focuses on three programmatic areas- Basic Neuroscience, Clinical / Translational Neuroscience and Genetics- and our primary goal is to identify the causes of and develop therapies for children with intellectual and developmental disabilities. The research of this IDDRC encompasses laboratory research on fundamental processes of normal and abnormal neurodevelopment and plasticity, as well as clinical and behavioral studies directed at disorders including, but not limited to, autistic spectrum disorders brain injury, neuro-oncology, learning and cognitive disabilities, the effects of surgery and environmental toxins on neural development, and multiple neurogenetic disorders, including those that affect neural formation, migration, specification and synaptic connectivity, as well as muscular dystrophy.
The goals of this IDDRC are threefold;support outstanding research into the causes of Intellectual and developmental disorders, train the next generation of researchers in this field, and finally develop new therapies for children with these disabilities. Ultimately, these goals are directed toward improving the quality of life f children with IDD, to enable them to achieve their maximal potential as adults.
|VanderVeen, Deborah K; Allred, Elizabeth N; Wallace, David K et al. (2016) Strabismus at Age 2 Years in Children Born Before 28 Weeks' Gestation: Antecedents and Correlates. J Child Neurol 31:451-60|
|Park, Jong G; Tischfield, Max A; Nugent, Alicia A et al. (2016) Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. Am J Hum Genet 98:1220-7|
|Hefti, Marco M; Trachtenberg, Felicia L; Haynes, Robin L et al. (2016) A Century of Germinal Matrix Intraventricular Hemorrhage in Autopsied Premature Infants: AÂ Historical Account. Pediatr Dev Pathol 19:108-14|
|Lippman-Bell, Jocelyn J; Zhou, Chengwen; Sun, Hongyu et al. (2016) Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity. Mol Cell Neurosci 76:11-20|
|Joyal, Jean-SÃ©bastien; Sun, Ye; Gantner, Marin L et al. (2016) Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med 22:439-45|
|HellstrÃ¶m, Ann; Ley, David; Hansen-Pupp, Ingrid et al. (2016) IGF-I in the clinics: Use in retinopathy of prematurity. Growth Horm IGF Res 30-31:75-80|
|Gong, Yan; Fu, Zhongjie; Edin, Matthew L et al. (2016) Cytochrome P450 Oxidase 2C Inhibition Adds to Ï‰-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol 36:1919-27|
|Shlevkov, Evgeny; Kramer, Tal; Schapansky, Jason et al. (2016) Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc Natl Acad Sci U S A 113:E6097-E6106|
|Jabara, Haifa H; Boyden, Steven E; Chou, Janet et al. (2016) A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet 48:74-8|
|Faden, Maheer; Holm, Mari; Allred, Elizabeth et al. (2016) Antenatal glucocorticoids and neonatal inflammation-associated proteins. Cytokine 88:199-208|
Showing the most recent 10 out of 1316 publications